The correlation between obesity-related diseases and non-alcoholic fatty liver disease in women in the pre-operative evaluation for bariatric surgery assessed by transient hepatic elastography

dc.creatorBarros, Fernando de
dc.creatorSetúbal, Sérgio
dc.creatorMartinho, José Manoel
dc.creatorLeite, Nathalie Carvalho
dc.creatorGuaraná, Thais
dc.creatorMonteiro, Ana Beatriz Soares
dc.creatorVillela-Nogueira, Cristiane A.
dc.date2019-04-18T14:11:32Z
dc.date2019-04-18T14:11:32Z
dc.date2016
dc.date.accessioned2023-09-26T22:52:47Z
dc.date.available2023-09-26T22:52:47Z
dc.identifierBARROS, Fernando de et al. The correlation between obesity-related diseases and non-alcoholic fatty liver disease in women in the pre-operative evaluation for bariatric surgery assessed by transient hepatic elastography. Obesity Surgery, v. 26, p. 2089-2097, 2016.
dc.identifier0960-8923
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/32593
dc.identifier10.1007/s11695-016-2054-y
dc.identifier1708-0428
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8884293
dc.descriptionBackground: Non-alcoholic fatty liver disease (NAFLD) is a common, severe disease in obese patients. However, NAFLD is usually underestimated by ultrasonography. Liver biopsy is not routinely done in bariatric surgery or during the follow-up. This study therefore examined the correlation between metabolic syndrome and NAFLD in morbidly obese patients based on an assessment using transient hepatic elastography (THE). Material and Methods: This study involved 50 female patients in the pre-operative phase for bariatric surgery. Before surgery, we collected clinical, laboratory, and anthropometric variables. THE measurements were obtained using a FibroScan® device (Echosens, Paris, France), and steatosis was quantified using Controlled Attenuation Parameter software (CAP). Statistical analyses were done using linear correlation and the Kruskal-Wallis test. Results: The mean of THE and CAP values were 7.56± 4.78 kPa and 279.94 ± 45.69 dB/m, respectively, and there was a significant linear correlation between the two measurements (r = 0.651; p< 0.001). The numbers of metabolic syndrome parameters did not influence the THE (p = 0.436) or CAP (p = 0.422) values. HbA1c and HOMA-IR showed a strong linear correlation with CAP (r= 0.643, p = 0.013 and r= 0.668, p = 0.009, respectively) and a tendency to some linear correlation with THE (r = 0.500, p = 0.05 and r = 0.500, p = 0.002, respectively). Conclusion: Morbidly obese women submitted to FibroScan® presented a high prevalence of severe steatosis and advanced fibrosis in our sample. Insulin resistance parameters were correlated with steatosis, but less with fibrosis.
dc.description2020-04-15
dc.formatapplication/pdf
dc.languageeng
dc.publisherSpringer Verlag
dc.rightsopen access
dc.subjectBariatric surgery
dc.subjectFatty liver
dc.subjectMetabolic syndrome X
dc.subjectMorbid obesity
dc.subjectNon-invasive test
dc.subjectTransient elastography
dc.titleThe correlation between obesity-related diseases and non-alcoholic fatty liver disease in women in the pre-operative evaluation for bariatric surgery assessed by transient hepatic elastography
dc.typeArticle


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