Clinical, histologic and serologic evaluation of patients with acute non-A-E hepatitis in north-eastern Brazil: is it an infectious disease?

dc.creatorParaná, Raymundo
dc.creatorCodes, Liana
dc.creatorAndrade, Zilton de Araújo
dc.creatorFreitas, Luiz Antonio Rodrigues de
dc.creatorJesus, Rogério Santos
dc.creatorReis, Mitermayer Galvão dos
dc.creatorCotrim, Helma Pinchemel
dc.creatorCunha, Simone
dc.creatorTrépo, Christian
dc.date2014-04-30T16:31:43Z
dc.date2014-04-30T16:31:43Z
dc.date2003
dc.date.accessioned2023-09-26T22:52:45Z
dc.date.available2023-09-26T22:52:45Z
dc.identifierPARANÁ, R. et al. Clinical, histologic and serologic evaluation of patients with acute non-A-E hepatitis in north-eastern Brazil: is it an infectious disease? International Journal of Infectious Disease, v. 7, n. 3, p. 222-230, 2003.
dc.identifier1201-9712
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/7559
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8884288
dc.descriptionNon-A-E hepatitis and acute cryptogenic hepatitis are the names given to the disease of patients with clinical hepatitis, but in whom serologic evidence of A-E hepatitis has not been found. Over a period of 8 years, we evaluated in Brazil 32 patients who fulfilled the criteria for this diagnosis in order to determine patterns of the clinical illness, laboratory parameters, or histologic features. Each patient was subjected to virologic tests to exclude A-E hepatitis and cytomegalovirus/Epstein-Barr virus infection. Drug-induced hepatitis and autoimmune disease were also excluded. Wilson's disease was excluded in young patients. The course of the disease was clinical/biochemical recovery in 3 months in 25 patients and persistent alanine aminotransferase (ALT) elevation in 7 patients. Three of these had chronic hepatitis, and one had severe fibrosis on liver biopsy. During the acute illness, mean peak ALT was 1267 IU/L, bilirubin was 4.0 mg/dL, and ferritin was 1393 IU/mL. GB virus type C (GBV-C) was found in six patients, and TT virus (TTV) in five patients. We conclude that, in Brazil, non-A-E hepatitis probably originates from still unidentified viruses. The course of the disease and the histologic patterns are similar to those recorded for known viruses. Continuous survey for the specific etiologic agents is needed.
dc.formatapplication/pdf
dc.languageeng
dc.publisherInternational Society for Infectious Diseases
dc.rightsopen access
dc.subjectVírus GB C/isolamento & purificação
dc.subjectHepatite Viral Humana/fisiopatologia
dc.subjectHepatite Viral Humana/virologia
dc.subjectTorque teno virus/isolamento & purificação
dc.subjectDoença Aguda
dc.subjectAdolescente
dc.subjectAdulto
dc.subjectAlanina Transaminase/sangue
dc.subjectAnticorpos Antivirais/sangue
dc.subjectBrasil
dc.subjectCriança
dc.subjectEstudos de Coortes
dc.subjectDoenças Transmissíveis/virologia
dc.subjectFeminino
dc.subjectHepatite Viral Humana/imunologia
dc.subjectHumanos
dc.subjectFígado/patologia
dc.subjectMasculino
dc.subjectMeia-Idade
dc.titleClinical, histologic and serologic evaluation of patients with acute non-A-E hepatitis in north-eastern Brazil: is it an infectious disease?
dc.typeArticle


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