Diethylcarbamazine attenuates the expression of pro-fibrogenic markers and hepatic stellate cells activation in carbon tetrachloride-induced liver fibrosis

dc.creatorFrança, Maria Eduarda Rocha de
dc.creatorRocha, Sura Wanessa Santos
dc.creatorOliveira, Wilma Helena
dc.creatorSantos, Laise Aline
dc.creatorOliveira, Anne Gabrielle Vasconcelos de
dc.creatorBarbosa, Karla Patrícia Sousa
dc.creatorNunes, Ana Karolina Santana
dc.creatorRodrigues, Gabriel Barros
dc.creatorLós, Deniele Bezerra
dc.creatorPeixoto, Christina Alves
dc.date2019-11-22T14:31:31Z
dc.date2019-11-22T14:31:31Z
dc.date2018
dc.date.accessioned2023-09-26T22:52:42Z
dc.date.available2023-09-26T22:52:42Z
dc.identifierFRANÇA, Maria Eduarda Rocha de et al. Diethylcarbamazine attenuates the expression of pro-fibrogenic markers and hepatic stellate cells activation in carbon tetrachloride-induced liver fibrosis. Inflammopharmacology, v. 26, n. 2, p. 599–609, abr. 2018.
dc.identifier0925-4692
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/37294
dc.identifier10.1007/s10787-017-0329-0
dc.identifier1568-5608
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8884277
dc.descriptionCAPES; UFPE; IAM / FIOCRUZ
dc.descriptionWhile diethylcarbamazine citrate (DEC) displays important anti-inflammatory effects in experimental models of liver injury, the mechanisms of its action remain poorly understood. The aim of the present study was to investigate the fibrolytic potential of DEC.
dc.description2050-01-01
dc.formatapplication/pdf
dc.languageeng
dc.rightsrestricted access
dc.subjectCarbon tetrachloride (CCl4)
dc.subjectDiethylcarbamazine citrate
dc.subjectLiver fibrosis
dc.subjectActinas / metabolismo
dc.subjectAnimais
dc.subjectBiomarcadores / metabolismo
dc.subjectTetracloreto de Carbono / farmacologia
dc.subjectColágeno Tipo I / metabolismo
dc.subjectDietilcarbamazina / farmacologia
dc.subjectRegulação para Baixo / /efeitos dos fármacos
dc.subjectCélulas Estreladas do Fígado / drug effects
dc.subjectCélulas Estreladas do Fígado / metabolismo
dc.subjectFígado / efeitos dos fármacos
dc.subjectFígado / metabolismo
dc.subjectCirrose Hepática / induzido quimicamente
dc.subjectCirrose Hepática / tratamento farmacológico
dc.subjectCirrose Hepática / metabolismo
dc.subjectMasculino
dc.subjectMetaloproteinase 2 da Matriz / metabolismo
dc.subjectCamundongos
dc.subjectCamundongos Endogâmicos C57BL
dc.subjectNF-kappa B / metabolismo
dc.subjectTransdução de Sinais / Efeitos Colaterais Metabólicos de Drogas e Substâncias
dc.subjectInibidor Tecidual de Metaloproteinase-1 / metabolismo
dc.subjectFator de Crescimento Transformador beta1 / metabolismo
dc.subjectProteínas Quinases p38 Ativadas por Mitógeno / metabolismo
dc.titleDiethylcarbamazine attenuates the expression of pro-fibrogenic markers and hepatic stellate cells activation in carbon tetrachloride-induced liver fibrosis
dc.typeArticle


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