dc.creatorNielebock, Marco Antonio Prates
dc.creatorMoreira, Otacilio Cruz
dc.creatorXavier, Samanta Cristina das Chagas
dc.creatorMiranda, Luciana de Freitas Campos
dc.creatorLima, Ana Carolina Bastos de
dc.creatorPereira, Thayanne Oliveira de Jesus Sales
dc.creatorHaaslocher-Moreno, Alejandro Maciel
dc.creatorBritto, Constança
dc.creatorSangenis, Luiz Henrique Conde
dc.creatorSaraiva, Roberto Magalhães
dc.date2020-12-09T14:56:45Z
dc.date2020-12-09T14:56:45Z
dc.date2020
dc.date.accessioned2023-09-26T22:51:54Z
dc.date.available2023-09-26T22:51:54Z
dc.identifierNIELEBOCK, Marco Antonio Prates et al. Association between Trypanosoma cruzi DTU TcII and chronic Chagas disease clinical presentation and outcome in an urban cohort in Brazil. Plos One, v. 15, n. 2, e0243008, p. 1-15, Dec. 2020.
dc.identifier1932-6203
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/44756
dc.identifier10.1371/journal.pone.0243008
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8884116
dc.descriptionBackground: The specific roles of parasite characteristics and immunological factors of the host in Chagas disease progression and prognosis are still under debate. Trypanosoma cruzi genotype may be an important determinant of the clinical chronic Chagas disease form and prognosis. This study aimed to identify the potential association between T. cruzi genotypes and the clinical presentations of chronic Chagas disease. Methodology/principal findings: This is a retrospective study using T. cruzi isolated from blood culture samples of 43 patients with chronic Chagas disease. From 43 patients, 42 were born in Brazil, mainly in Southeast and Northeast Brazilian regions, and one patient was born in Bolivia. Their mean age at the time of blood collection was 52.4±13.2 years. The clinical presentation was as follows 51.1% cardiac form, 25.6% indeterminate form, and 23.3% cardiodigestive form. Discrete typing unit (DTU) was determined by multilocus conventional PCR. TcII (n = 40) and TcVI (n = 2) were the DTUs identified. DTU was unidentifiable in one patient. The average follow-up time after blood culture was 5.7±4.4 years. A total of 14 patients (32.5%) died and one patient underwent heart transplantation. The cause of death was sudden cardiac arrest in six patients, heart failure in five patients, not related to Chagas disease in one patient, and ignored in two patients. A total of 8 patients (18.6%) progressed, all of them within the cardiac or cardiodigestive forms. Conclusions/significance: TcII was the main T. cruzi DTU identified in chronic Chagas disease Brazilian patients (92.9%) with either cardiac, indeterminate or cardiodigestive forms, born at Southeast and Northeast regions. Other DTU found in much less frequency was TcVI (4.8%). TcII was also associated to patients that evolved with heart failure or sudden cardiac arrest, the two most common and ominous consequences of the cardiac form of Chagas disease.
dc.formatapplication/pdf
dc.languageeng
dc.publisherPublic Library of Science
dc.rightsopen access
dc.subjectDoença de Chagas Crônica
dc.subjectCoorte urbano
dc.subjectApresentação clínica
dc.subjectTrypanosoma cruzi DTU TcII
dc.subjectBrasil
dc.subjectTrypanosoma cruzi DTU TcII
dc.subjectChronic Chagas Disease
dc.subjectUrban cohort
dc.subjectBrazil
dc.subjectClinical presentation
dc.titleAssociation between Trypanosoma cruzi DTU TcII and chronic Chagas Disease clinical presentation and outcome in an urban cohort in Brazil
dc.typeArticle


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