Laboratory Diagnosis of Late-Onset Male Hypogonadism Andropause
Diagnóstico Laboratorial do Hipogonadismo Masculino Tardio (An-dropausa)
| dc.creator | Clapauch, Ruth | |
| dc.creator | Carmo, Aline Machado | |
| dc.creator | Marinheiro, Lizanka Paola Figueiredo | |
| dc.creator | Buksman, Salo | |
| dc.creator | Pessoa, Isabel | |
| dc.date | 2015-02-09T13:48:08Z | |
| dc.date | 2015-02-09T13:48:08Z | |
| dc.date | 2008 | |
| dc.date.accessioned | 2023-09-26T22:51:53Z | |
| dc.date.available | 2023-09-26T22:51:53Z | |
| dc.identifier | CLAPAUCH, Ruth. et al. Laboratory diagnosis of late-onset male hypogonadism andropause. Arq. bras. endocrinol. metab., São Paulo, v. 52, n. 9, p. 1430-1438, 2008. | |
| dc.identifier | 0004-2730 | |
| dc.identifier | https://www.arca.fiocruz.br/handle/icict/9459 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/8884110 | |
| dc.description | Objetivos:Avaliar os fatores que influenciam o diagnóstico laboratorial do hipogonadismo masculino tardio. Métodos:Avaliamos 216 homens entre 52 e 84 anos. O diagnóstico laboratorial foi definido como dois valores de testos-terona livre calculada (TLC) <6,5 ng/dl, segundo a fórmula de Vermeulen, a partir das dosagens de testosterona total (TT), SHBG e albumina. Resultados: Na primeira dosagem, a TLC foi <6.5 ng/dl em 27% da amostra. Hipogonad-ismo laboratorial (confi rmado por duas dosagens) esteve presente em 19%, no entanto a TT foi baixa em apenas 4.1% dos homens. A idade influenciou a TT (p=0.0051) bem como o IMC; 23,5% dos homens ≥70 anos e 38,9% dos obesos com TT dentro dos níveis de referência eram, na verdade, hipogonádi-cos. Conclusão:Especialmente em homens obesos e nos ≥70 anos a dosa-gem de SHBG é importante para calcular TL e diagnosticar o hipogonadismo. | |
| dc.description | Objectives: To evaluate which factors influence the laboratorial diagnosis of late-onset male hypogonadism (LOH). Methods:Total testosterone (TT), SHBG and albumin were measured in 216 men aged 52-84 years. The labora-torial definition of LOH was two values of calculated free testosterone (cFT) <6.5 ng/dl, according to Vermeulen’s formula. Results:At the first blood test, cFT was <6.5 ng/dl in 27% of the men. Laboratorial LOH (confirmed by two tests) was present in 19%, but TT levels were low in only 4.1%. Age influenced TT (p=0.0051) as well as BMI; 23.5% of patients ≥70 years and 38.9% of the obese men who had TT within the reference range were, in fact, hypogonad-al. Conclusion: Especially in obese men and in those ≥70 years old, SHBG dosage is important to calculate FT levels and diagnose hypogonadism. | |
| dc.format | application/pdf | |
| dc.language | eng | |
| dc.publisher | Sociedade Brasileira de Endocrinologia e Metabologia | |
| dc.rights | open access | |
| dc.subject | Andropausa | |
| dc.subject | Hipogonadismo Masculino Tardio | |
| dc.subject | Diagnóstico | |
| dc.subject | Testosterona Total | |
| dc.subject | Testosterona Livre Calculada | |
| dc.subject | Andropause | |
| dc.subject | Late-Onset Male Hypogonadism | |
| dc.subject | Diagnosis | |
| dc.subject | Total Testosterone | |
| dc.subject | Calculated Free Testosterone | |
| dc.subject | Andropausa | |
| dc.subject | Hipogonadismo | |
| dc.subject | Diagnóstico | |
| dc.subject | Testosterona | |
| dc.title | Laboratory Diagnosis of Late-Onset Male Hypogonadism Andropause | |
| dc.title | Diagnóstico Laboratorial do Hipogonadismo Masculino Tardio (An-dropausa) | |
| dc.type | Article |