Trypanosoma rangeli Genetic, Mammalian Hosts, and Geographical Diversity from Five Brazilian Biomes

dc.creatorDario, Maria Augusta
dc.creatorPavan, Márcio Galvão
dc.creatorRodrigues, Marina Silva
dc.creatorLisboa, Cristiane Varella
dc.creatorKluyber, Dario
dc.creatorDesbiez, Arnaud L. J.
dc.creatorHerrera, Heitor Miraglia
dc.creatorRoque, André Luiz Rodrigues
dc.creatorLima, Luciana
dc.creatorTeixeira, Marta M. G.
dc.creatorJansen, Ana Maria
dc.date2021-08-01T18:29:47Z
dc.date2021-08-01T18:29:47Z
dc.date2021
dc.date.accessioned2023-09-26T22:51:50Z
dc.date.available2023-09-26T22:51:50Z
dc.identifierDARIO, Maria Augusta et al. Trypanosoma rangeli Genetic, Mammalian Hosts, and Geographical Diversity from Five Brazilian Biomes. Pathogens, v. 10, n.736, 18 p, June 2021.
dc.identifier2076-0817
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/48461
dc.identifier10.3390/pathogens10060736
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8884101
dc.descriptionAbstract: Trypanosoma rangeli is a generalist hemoflagellate that infects mammals and is transmitted by triatomines around Latin America. Due to its high genetic diversity, it can be classified into two to five lineages. In Brazil, its distribution outside the Amazon region is virtually unknown, and knowledge on the ecology of its lineages and on host species diversity requires further investigation. Here, we analyzed 57 T. rangeli samples obtained from hemocultures and blood clots of 1392 mammals captured in different Brazilian biomes. The samples were subjected to small subunit (SSU) rDNA amplification and sequencing to confirm T. rangeli infection. Phylogenetic inferences and haplotype networks were reconstructed to classify T. rangeli lineages and to infer the genetic diversity of the samples. The results obtained in our study highlighted both the mammalian host range and distribution of T. rangeli in Brazil: infection was observed in five new species (Procyon cancrivorous, Priodontes maximum, Alouatta belzebul, Sapajus libidinosus, and Trinomys dimidiatus), and transmission was observed in the Caatinga biome. The coati (Nasua nasua) and capuchin monkey (S. libidinosus) are the key hosts of T. rangeli. We identified all four T. rangeli lineages previously reported in Brazil (A, B, D, and E) and possibly two new genotypes.
dc.formatapplication/pdf
dc.languageeng
dc.publisherMDPI
dc.rightsopen access
dc.subjectTrypanosoma rangeli
dc.subjectMamíferos
dc.subjectEcologia de parasitas
dc.subjectLinhagens
dc.subjectBiomas brasileiros
dc.subjectTrypanosoma rangeli
dc.subjectMammals
dc.subjectParasite ecology
dc.subjectLineages
dc.subjectBrazilian biomes
dc.titleTrypanosoma rangeli Genetic, Mammalian Hosts, and Geographical Diversity from Five Brazilian Biomes
dc.typeArticle


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