Bladder exstrophy: an epidemiologic study from the International Clearinghouse for Birth Defects Surveillance and Research, and an overview of the literature

dc.creatorSiffel, Csaba
dc.creatorCorrea, Adolfo
dc.creatorAmar, Emmanuelle
dc.creatorBakker, Marian K.
dc.creatorBermejo-Sánchez, Eva
dc.creatorBianca, Sebastiano
dc.creatorCastilla, Eduardo E.
dc.creatorClementi, Maurizio
dc.creatorCocchi, Guido
dc.creatorCsáky-Szunyogh, Melinda
dc.creatorFeldkamp, Marcia L.
dc.creatorLandau, Danielle
dc.creatorLeoncini, Emanuele
dc.creatorLi, Zhu
dc.creatorLowry, R. Brian
dc.creatorMarengo, Lisa K.
dc.creatorMastroiacovo, Pierpaolo
dc.creatorMorgan, Margery
dc.creatorMutchinick, Osvaldo M.
dc.creatorPierini, Anna
dc.creatorRissmann, Anke
dc.creatorRitvanen, Annukka
dc.creatorScarano, Gioacchino
dc.creatorSzabova, Elena
dc.creatorOlney, Richard S.
dc.date2017-01-05T11:39:49Z
dc.date2017-01-05T11:39:49Z
dc.date2011
dc.date.accessioned2023-09-26T22:51:34Z
dc.date.available2023-09-26T22:51:34Z
dc.identifierSIFFEL, Csaba; et al. Bladder Exstrophy: An Epidemiologic Study From the International Clearinghouse for Birth Defects Surveillance and Research, and an Overview of the Literature. Am J Med Genet C Semin Med Genet. , v. 0, n.4, p.321–332, Nov. 2011.
dc.identifier1552-4868
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/16721
dc.identifier10.1002/ajmg.c.30316
dc.identifier1552-4876
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8884044
dc.descriptionBladder exstrophy (BE) is a complex congenital anomaly characterized by a defect in the closure of the lower abdominal wall and bladder. We aimed to provide an overview of the literature and conduct an epidemiologic study to describe the prevalence, and maternal and case characteristics of BE. We used data from 22 participating member programs of the International Clearinghouse for Birth Defects Surveillance and Research (ICBDSR). All cases were reviewed and classified as isolated, syndrome, and multiple congenital anomalies. We estimated the total prevalence of BE and calculated the frequency and odds ratios for various maternal and case characteristics. A total of 546 cases with BE were identified among 26,355,094 births. The total prevalence of BE was 2.07 per 100,000 births (95% CI: 1.90-2.25) and varied between 0.52 and 4.63 among surveillance programs participating in the study. BE was nearly twice as common among male as among female cases. The proportion of isolated cases was 71%. Prevalence appeared to increase with increasing categories of maternal age, particularly among isolated cases. The total prevalence of BE showed some variations by geographical region, which is most likely attributable to differences in registration of cases. The higher total prevalence among male cases and older mothers, especially among isolated cases, warrants further attention.
dc.description2030-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherWiley
dc.rightsrestricted access
dc.subjectExtrofia Vesical
dc.subjectIdade materna
dc.subjectRazão de Masculinidade
dc.subjectPrevalência
dc.subjectbladder exstrophy
dc.subjectprevalence
dc.subjectsex ratio
dc.subjectmaternal age
dc.titleBladder exstrophy: an epidemiologic study from the International Clearinghouse for Birth Defects Surveillance and Research, and an overview of the literature
dc.typeArticle


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