CD4 T cells are rapidly depleted from tuberculosis granulomas following acute SIV co-infection

dc.creatorForeman, Taylor W
dc.creatorNelson, Christine E
dc.creatorKauffman, Keith D
dc.creatorLora, Nickiana E
dc.creatorVinhaes, Caian L
dc.creatorDorosky, Danielle E
dc.creatorSakai, Shunsuke
dc.creatorGomez, Felipe
dc.creatorFleegle, Joel D
dc.creatorParham, Melanie
dc.creatorPerera, Shehan R
dc.creatorArlehamn, Cecilia S. Lindestam
dc.creatorSette, Alessandro
dc.creatorTuberculosis Imaging Program
dc.creatorBrenchley, Jason M
dc.creatorQueiroz, Artur T. L
dc.creatorAndrade, Bruno B
dc.creatorKabat, Juraj
dc.creatorVia, Laura E
dc.creatorBarber, Daniel L
dc.date2022-10-11T19:27:42Z
dc.date2022-10-11T19:27:42Z
dc.date2022
dc.date.accessioned2023-09-26T22:51:31Z
dc.date.available2023-09-26T22:51:31Z
dc.identifierFOREMAN, Taylor W. et al. CD4 T cells are rapidly depleted from tuberculosis granulomas following acute SIV co-infection. Cell Reports, v. 39, p. 1-16, 2022.
dc.identifier2211-1247
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/55116
dc.identifier10.1016/j.celrep.2022.110896
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8884036
dc.descriptionIntramural AIDS Research Fellowship, Office of Intramural Training and Education. Division of Intramural Research, National Institute of Allergy and Infectious Diseases. Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Programa de Pesquisa Intermural da Fundação Oswaldo Cruz.
dc.descriptionHIV/Mycobacterium tuberculosis (Mtb) co-infected individuals have an increased risk of tuberculosis prior to loss of peripheral CD4 T cells, raising the possibility that HIV co-infection leads to CD4 T cell depletion in lung tissue before it is evident in blood. Here, we use rhesus macaques to study the early effects of simian immunodeficiency virus (SIV) co-infection on pulmonary granulomas. Two weeks after SIV inoculation of Mtb-infected macaques, Mtb-specific CD4 T cells are dramatically depleted from granulomas, before CD4 T cell loss in blood, airways, and lymph nodes, or increases in bacterial loads or radiographic evidence of disease. Spatially, CD4 T cells are preferentially depleted from the granuloma core and cuff relative to B cell-rich regions. Moreover, live imaging of granuloma explants show that intralesional CD4 T cell motility is reduced after SIV co-infection. Thus, granuloma CD4 T cells may be decimated before many co-infected individuals experience the first symptoms of acute HIV infection.
dc.formatapplication/pdf
dc.languageeng
dc.publisherCell Press
dc.rightsopen access
dc.subjectHIV
dc.subjectMycobacterium tuberculosis
dc.subjectCélulas T CD4
dc.subjectCo-infecção SIV
dc.subjectHIV
dc.subjectMycobacterium tuberculosis
dc.subjectCD4 T cells
dc.subjectSIV co-infection
dc.titleCD4 T cells are rapidly depleted from tuberculosis granulomas following acute SIV co-infection
dc.typeArticle


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