Indomethacin treatment slows disease progression and enhances a Th1 response in susceptible BALB/c mice infected with Leishmania major.

dc.creatorFreitas, Luiz Antonio Rodrigues de
dc.creatorMbow, M. Lamine
dc.creatorEstay, Monica
dc.creatorBleyenberg, Julie A
dc.creatorTitus, Richard G
dc.date2014-07-10T12:30:06Z
dc.date2014-07-10T12:30:06Z
dc.date1999
dc.date.accessioned2023-09-26T22:49:28Z
dc.date.available2023-09-26T22:49:28Z
dc.identifierFREITAS, L. A. R. et al. Indomethacin treatment slows disease progression and enhances a Th1 response in susceptible BALB/c mice infected with Leishmania major. Parasite Immunology, v. 21, n. 5, p. 273-277, 1999.
dc.identifier0141-9838
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/7900
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8883639
dc.descriptionProstaglandins of the E series inhibit the development of Th1 responses. When infected with Leishmania major, BALB/c mice fail to develop a Th1 response, but instead mount a Th2 response and die of the disease. Therefore, we treated L. major-infected BALB/c mice with indomethacin, which inhibits prostaglandin production. Indomethacin lessened disease severity (parasite burden and pathology), and promoted a Th1 response, but the mice still succumbed to infection. The explanation for these observations may be two-fold: (1) the beneficial effects of indomethacin were predominantly observed later in infection (beyond two weeks), a time at which indomethacin was unable to sufficiently block the development of a Th2 response; (2) indomethacin was unable to induce a Th1 response in BALB/c mice that was of the same magnitude as the Th1 response observed in C57BL/6 mice infected with L. major.
dc.formatapplication/pdf
dc.languageeng
dc.publisherBlackwell Science
dc.rightsopen access
dc.subjectLeishmania major
dc.subjectLeishmaniasis
dc.subjectProstaglandins
dc.subjectCytokines
dc.subjectNitric oxide
dc.subjectAntiprotozoários/uso terapêutico
dc.subjectIndometacina/uso terapêutico
dc.subjectLeishmania major
dc.subjectLeishmaniose Cutânea/quimioterapia
dc.subjectCélulas Th1/imunologia
dc.subjectAnimais
dc.subjectInibidores de Ciclo-Oxigenase/uso terapêutico
dc.subjectProgressão da Doença
dc.subjectFeminino
dc.subjectImunidade Celular
dc.subjectLeishmaniose Cutânea/imunologia
dc.subjectCamundongos
dc.subjectCamundongos Endogâmicos BALB C
dc.subjectAntagonistas de Prostaglandina/uso terapêutico
dc.titleIndomethacin treatment slows disease progression and enhances a Th1 response in susceptible BALB/c mice infected with Leishmania major.
dc.typeArticle


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