Flavonols and Flavones as Potential anti-Inflammatory, Antioxidant, and Antibacterial Compounds

dc.creatorChagas, Maria do Socorro S.
dc.creatorBehrens, Maria D.
dc.creatorMoragas-Tellis, Carla J.
dc.creatorPenedo, Gabriela X. M.
dc.creatorSilva, Adriana R.
dc.creatorAlbuquerque, Cassiano F. Gonçalves de
dc.date2022-10-20T19:41:22Z
dc.date2022-10-20T19:41:22Z
dc.date2022
dc.date.accessioned2023-09-26T22:48:56Z
dc.date.available2023-09-26T22:48:56Z
dc.identifierCHAGAS, Maria do Socorro S. et al. Flavonols and Flavones as Potential anti-Inflammatory, Antioxidant, and Antibacterial Compounds. Oxidative Medicine and Cellular Longevity, v. 2022, Article ID 9966750, 21p, 2022.
dc.identifier1942-0994
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/55216
dc.identifier10.1155/2022/9966750
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8883529
dc.descriptionPlant preparations have been used to treat various diseases and discussed for centuries. Research has advanced to discover and identify the plant components with beneficial effects and reveal their underlying mechanisms. Flavonoids are phytoconstituents with anti-inflammatory, antimutagenic, anticarcinogenic, and antimicrobial properties. Herein, we listed and contextualized various aspects of the protective effects of the flavonols quercetin, isoquercetin, kaempferol, and myricetin and the flavones luteolin, apigenin, 3′,4′-dihydroxyflavone, baicalein, scutellarein, lucenin-2, vicenin-2, diosmetin, nobiletin, tangeretin, and 5-Omethyl- scutellarein. We presented their structural characteristics and subclasses, importance, occurrence, and food sources. The bioactive compounds present in our diet, such as fruits and vegetables, may affect the health and disease state. Therefore, we discussed the role of these compounds in inflammation, oxidative mechanisms, and bacterial metabolism; moreover, we discussed their synergism with antibiotics for better disease outcomes. Indiscriminate use of antibiotics allows the emergence of multidrug-resistant bacterial strains; thus, bioactive compounds may be used for adjuvant treatment of infectious diseases caused by resistant and opportunistic bacteria via direct and indirect mechanisms. We also focused on the reported mechanisms and intracellular targets of flavonols and flavones, which support their therapeutic role in inflammatory and infectious diseases.
dc.formatapplication/pdf
dc.languageeng
dc.publisherHindawi
dc.rightsopen access
dc.subjectFlavonóis e Flavonas
dc.subjectPotencial Anti-Inflamatório
dc.subjectCompostos antioxidantes e antibacterianos
dc.subjectFlavonols and Flavones
dc.subjectPotential anti-Inflammatory
dc.subjectAntioxidant, and Antibacterial Compounds
dc.titleFlavonols and Flavones as Potential anti-Inflammatory, Antioxidant, and Antibacterial Compounds
dc.typeArticle


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