Proteomic map of Trypanosoma cruzi CL Brener: the reference strain of the genome project

dc.creatorSodré, Cátia Lacerda
dc.creatorChapeaurouge, Alexander D.
dc.creatorKalume, Dário Eluan
dc.creatorLima, Leila de Mendonça
dc.creatorPerales, Jonas
dc.creatorFernandes, Octavio
dc.date2018-07-17T13:13:45Z
dc.date2018-07-17T13:13:45Z
dc.date2009
dc.date.accessioned2023-09-26T22:48:47Z
dc.date.available2023-09-26T22:48:47Z
dc.identifierSODRÉ, Cátia Lacerda; et al. Proteomic map of Trypanosoma cruzi CL Brener: the reference strain of the genome project. Arch. Microbiol., v.191, p.177-184, 2009.
dc.identifier0302-8933
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/27559
dc.identifier10.1007/s00203-008-0439-6
dc.identifier1432-072X
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8883497
dc.descriptionIn this work two-dimensional gel electrophoresis combined with mass spectrometry was carried out in order to start the construction of a map of soluble proteins from epimastigote form of Trypanosoma cruzi CL Brener. This strain is a hybrid organism derived from two genotypes, T. cruzi I and T. cruzi II and was chosen for genome sequencing. The two-dimensional gel electrophoresis showed that most of proteins focused at 4-7 pH range. The identification demonstrated that several proteins were in multiple isoforms, such as tubulin and heat shock proteins. Potential targets for development of chemotherapeutic agents like arginine kinase, an enzyme absent from mammalian tissues that is involved in the energy supply of the parasite, were also detected.
dc.description2030-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherSpringer Verlag (Germany)
dc.rightsrestricted access
dc.subjectTrypanosoma cruzi
dc.subjectProteoma
dc.subjectProjeto Genoma
dc.subjectProteone
dc.subjectTrypanosoma cruzi
dc.subjectEpimastigote
dc.subjectCL Brener strain
dc.subjectgenome project
dc.titleProteomic map of Trypanosoma cruzi CL Brener: the reference strain of the genome project
dc.typeArticle


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