Cytokine production induced by marine algae lectins in BALB/c mice splenocytes

dc.creatorAbreu, Ticiana Monteiro
dc.creatorSilva, Luana Maria Castelo Melo
dc.creatorVanderlei, Edfranck Sousa Oliveira
dc.creatorMelo, Cristiane Moutinho Lagos de
dc.creatorPereira, Valeria Rego Alves
dc.creatorBenevides, Norma Maria Barros
dc.date2018-04-12T14:10:19Z
dc.date2018-04-12T14:10:19Z
dc.date2012
dc.date.accessioned2023-09-26T22:48:29Z
dc.date.available2023-09-26T22:48:29Z
dc.identifierMONTEIRO ABREU, T. et al. Cytokine production induced by marine algae lectins in BALB/c mice splenocytes. Protein and Peptide Letters, v. 19, n. 9, p. 975–981, set. 2012.
dc.identifier1875-5305
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/25805
dc.identifier10.2174/092986612802084474
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8883438
dc.descriptionEste trabalho foi apoiado por doações do Conselho Nacional de Desenvolvimento Científico e Tecnológico– CNPq, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES, Ministério da Ciência e Tecnologia - MCT, Ministério da Saúde-MS, Programa Rede Nordeste de Biotecnologia – RENORBIO / CNPq, Fundação Cearense de Apoio ao Desenvolvimento Científico e Tecnológico– FUNCAP e Centro de Pesquisas Aggeu Magalhães / FIOCRUZ
dc.descriptionMarine algae can serve as sources of bioactive compounds and currently have been shown their potential biological and pharmaceutical applications. Marine algae lectins have been shown to be effective at controlling inflammatory processes. This work aimed to analyze the immunostimulatory properties of lectins from the marine algae Solieria filiformis (SfL), Pterocladiella capillacea (PcL) and Caulerpa cupressoides (CcL). This analysis was performed on BALB/c mouse splenocytes by measuring cytokine and nitric oxide production and cellular damage using tests of cytotoxicity and cell viability. These lectins were not cytotoxic (1-100 μg/mL), and were not able to induce IFN-γ and IL-2 production. IL- 10 production was induced at high levels by all lectins tested. Treatment with SfL induced IL-6 production at higher levels at all experimental times, whereas treatment with PcL and CcL induced higher levels only in 24 and 72 h. Treatment with SfL did not result in nitrite oxide production, whereas treatment with PcL or CcL was able to induce nitrite release at high levels (after 24, 48 and 72 h). Lesser cellular damage (5%) was observed in splenocytes treated with these lectins (10 μg/mL). Thus, the lectins from these algae were not cytotoxic, promoted increased in cell viability and induced Th2 immune responses in mouse splenocytes, indicating that they have anti-inflammatory effects.
dc.description2050-01-01
dc.formatapplication/pdf
dc.languageeng
dc.rightsrestricted access
dc.subjectCitocinas
dc.subjectCitotoxicidade
dc.subjectimunomodulação
dc.subjectLectinas
dc.subjectAlgas marinhas
dc.subjectÓxido nítrico
dc.subjectCytokines
dc.subjectCytoxicity
dc.subjectImmunomodulation
dc.subjectLectins
dc.subjectMarine algae
dc.subjectNitric oxide
dc.subjectAdjuvantes Imunológicos / Química
dc.subjectAdjuvantes Imunológicos / Farmacologia
dc.subjectAnimais
dc.subjectSobrevivência Celular / efeitos de drogas
dc.subjectChlorophyta / química
dc.subjectCitocinas / imunologia
dc.subjectLectinas / química
dc.subjectLectinas / farmacologia
dc.subjectMasculino
dc.subjectRatos
dc.subjectRatos, endogâmicos BALB C
dc.subjectÓxido Nítrico / imunologia
dc.subjectRhodophyta / química
dc.subjectBaço / citologia
dc.subjectBaço / efeitos de drogas
dc.subjectCélulas Th2 / efeitos de drogas
dc.subjectCélulas Th2 / imunologia
dc.titleCytokine production induced by marine algae lectins in BALB/c mice splenocytes
dc.typeArticle


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