The Immune System Throws Its Traps: Cells and Their Extracellular Traps in Disease and Protection

dc.creatorSilva, Fátima Conceição
dc.creatorReis, Clarissa S. M
dc.creatorLuca, Paula Mello de
dc.creatorSilva, Jessica Leite
dc.creatorSantiago, Marta A.
dc.creatorMorrot, Alexandre
dc.creatorMorgado, Fernanda N.
dc.date2022-01-23T13:07:16Z
dc.date2022-01-23T13:07:16Z
dc.date2021
dc.date.accessioned2023-09-26T22:48:15Z
dc.date.available2023-09-26T22:48:15Z
dc.identifierSILVA, Fátima Conceição et al. The Immune System Throws Its Traps: Cells and Their Extracellular Traps in Disease and Protection. Cells, v. 10, 1891, p. 1-35, July 2021.
dc.identifier2073-4409
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/50849
dc.identifier10.3390/cells10081891
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8883387
dc.descriptionThe first formal description of the microbicidal activity of extracellular traps (ETs) containing DNA occurred in neutrophils in 2004. Since then, ETs have been identified in different populations of cells involved in both innate and adaptive immune responses. Much of the knowledge has been obtained from in vitro or ex vivo studies; however, in vivo evaluations in experimental models and human biological materials have corroborated some of the results obtained. Two types of ETs have been described—suicidal and vital ETs, with or without the death of the producer cell. The studies showed that the same cell type may have more than one ETs formation mechanism and that different cells may have similar ETs formation mechanisms. ETs can act by controlling or promoting the mechanisms involved in the development and evolution of various infectious and non-infectious diseases, such as autoimmune, cardiovascular, thrombotic, and neoplastic diseases, among others. This review discusses the presence of ETs in neutrophils, macrophages, mast cells, eosinophils, basophils, plasmacytoid dendritic cells, and recent evidence of the presence of ETs in B lymphocytes, CD4+ T lymphocytes, and CD8+ T lymphocytes. Moreover, due to recently collected information, the effect of ETs on COVID-19 is also discussed.
dc.formatapplication/pdf
dc.languageeng
dc.publisherMDPI
dc.rightsopen access
dc.subjectCOVID-19
dc.subjectArmadilhas extracelulares (ETs)
dc.subjectETs de neutrófilos
dc.subjectETs de mastócitos
dc.subjectETs de eosinófilos
dc.subjectETs de linfócitos
dc.subjectETs basófilos
dc.subjectETs de células dendríticas
dc.subjectETs de macrófagos
dc.subjectExtracellular traps (ETs)
dc.subjectNeutrophils ETs
dc.subjectMacrophage ETs
dc.subjectMast cell ETs
dc.subjectEosinophil ETs
dc.subjectLymphocyte ETs
dc.subjectBasophil ETs
dc.subjectDendritic cell ETs
dc.subjectCOVID-19
dc.titleThe Immune System Throws Its Traps: Cells and Their Extracellular Traps in Disease and Protection
dc.typeArticle


Este ítem pertenece a la siguiente institución