Acute schistosomiasis diagnosis: a new tool for the diagnosis of schistosomiasis in a group of travelers recently infected in a new focus of Schistosoma mansoni

dc.creatorGrenfell, Rafaella Fortini Queiroz
dc.creatorMartins, Watson Mauricio Herman
dc.creatorDrummond, Sandra Costa
dc.creatorAntunes, Carlos Maurício de Figueiredo
dc.creatorVoieta, Izabela
dc.creatorOtoni, Alba
dc.creatorOliveira, Áureo Almeida de
dc.creatorMoraes, Vanessa Silva
dc.creatorOliveira, Eduardo Ribeiro de
dc.creatorOliveira, Edward José de
dc.creatorLambertucci, José Roberto
dc.creatorFonseca, Cristina Toscano
dc.creatorCoelho, Paulo Marcos Zach
dc.date2013-06-03T15:58:30Z
dc.date2013-06-03T15:58:30Z
dc.date2013
dc.date.accessioned2023-09-26T22:47:41Z
dc.date.available2023-09-26T22:47:41Z
dc.identifierGRENFELL, Rafaella Fortini Queiroz et al. Acute schistosomiasis diagnosis: a new tool for the diagnosis of schistosomiasis in a group of travelers recently infected in a new focus of Schistosoma manson.i Rev. Soc. Bras. Med. Trop . 2013, vol.46, n.2, pp. 208-213
dc.identifier0037-8682
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/6545
dc.identifier10.1590/0037-8682-0064-2012
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8883267
dc.descriptionIntroduction The diagnosis of schistosomiasis mansoni on early stages of infection is important to prevent late morbidity. A simple, cheap, sensitive and specific assay for routine diagnosis of schistosome infection based on the detection of specific IgG for schistosomula tegument antigens (ELISA-SmTeg) was developed by our group. Methods We describe here an acute outbreak involving a travel group of 80 individuals from a non-endemic area of the State of Minas Gerais, Brazil. These individuals were in contact with a freshwater pool where Biomphalaria glabrata was found. Results obtained from our new methodology were compared to IgG antibody titers against soluble worm antigenic preparation (SWAP) by ELISA and, also to parasitological examination, nuclear magnetic resonance and clinical findings. Results ELISA-SmTeg was capable of detecting 64 positive cases among the 80 individuals participating at the survey with a positivity ratio of 80% and a higher sensitivity than ELISA-SWAP that was only sensitive for 56% of positive cases. Besides, a significant correlation was found for the severity of the infection and the specific IgG titers against SmTeg. Conclusions Our data showed that ELISA-SmTeg might serve as the initial diagnostic tool for acute stages of the infection in community-based helminth control programs or for the surveillance of individuals from non-endemic areas.
dc.formatapplication/pdf
dc.languageeng
dc.rightsopen access
dc.subjectSchistosomiasis mansoni
dc.subjectImmunological diagnosis
dc.subjectSchistosomula antigens
dc.subjectAcute outbreak
dc.titleAcute schistosomiasis diagnosis: a new tool for the diagnosis of schistosomiasis in a group of travelers recently infected in a new focus of Schistosoma mansoni
dc.typeArticle


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