Correlation between polymorphisms at interleukin-6 but not at interleukin-10 promoter and the risk of human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis in Brazilian individuals

dc.creatorGadelha, Sandra Rocha
dc.creatorAlcantara, Luiz Carlos Júnior
dc.creatorCosta, Giselle Calasans de Souza
dc.creatorAcosta, Angelina Xavier
dc.creatorRios, Domingos
dc.creatorKashima, Simone G
dc.creatorCovas, Dimas Tadeu
dc.creatorCastro Filho, Bernardo Galvão
dc.date2008
dc.date2011-04-12T22:21:50Z
dc.date2011-04-12T22:21:50Z
dc.date2008
dc.date.accessioned2023-09-26T22:47:13Z
dc.date.available2023-09-26T22:47:13Z
dc.identifierGADELHA, S. R. et al. Correlation between polymorphisms at interleukin-6 but not at interleukin-10 promoter and the risk of human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis in Brazilian individuals. Journal of Medical Virology, v.80, n.12, p.2141-2146, 2008.
dc.identifier0146-6615
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/1891
dc.identifier10.1002/jmv.21341
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8883170
dc.descriptionHTLV-1 is the etiologic agent of ATL and HAM/TSP. The majority of HTLV-1-infected individuals remain asymptomatic, indicating that the infection alone is not sufficient to cause the diseases. It has been reported that cytokine gene polymorphisms, including polymorphisms at IL-6 and IL-10 gene, might be important. We analyzed SNP in the promoter region of the IL-6: -174, -572, -597, and -634 positions, and IL-10: -592 position to evaluate the role of these polymorphisms in the HAM/TSP pathogenesis in 133 HTLV-1 infected individuals and in 100 healthy individuals from Salvador, Bahia, Brazil. The -634C allele frequencies were higher among HAM/TSP patients (21.2%) than among oligosymptomatic (6.5%; P = 0.038) and asymptomatic (9.5%; P = 0.025) subjects. Similarly, the -174G allele frequencies were higher in HAM/TSP patients than in oligosymptomatic patients (P = 0.02). Moreover, the -634GC/-174GG genotype combination was identified at a higher frequency (38.5%) in the HAM/TSP patients than in subjects with other clinical status (8.7%; P = 0.016 for oligosymptomatic and 15.5%, P = 0.012 for asymptomatic patients). However, the multivariate logistic regression including the genotypes of the three studied loci showed that only -634 C IL-6 carriers remain as significant and independent TSP/HAM predictor (odds ratio [OR] = 5.31; 95% [CI] = 1.60-17.56; P = 0.006). We suggest that -634 G C in IL-6 could contribute to HAM/TSP development and that identification of the collective influence of several cytokine polymorphisms, their prevalence, and their interaction could help to better understand this disease.
dc.formatapplication/pdf
dc.languageeng
dc.rightsopen access
dc.subjectHTLV-1
dc.subjectInterleukin-6
dc.subjectInterleukin-10
dc.subjectPolymorphisms
dc.subjectBrazilian populations
dc.subjectInfecções por HTLV-I
dc.subjectInterleucina-6
dc.subjectInterleucina-10
dc.subjectParaparesia Espástica Tropical
dc.subjectPolimorfismo de Um Único Nucleotídeo
dc.subjectRegiões Promotoras Genéticas
dc.subjectDoenças da Medula Espinal
dc.titleCorrelation between polymorphisms at interleukin-6 but not at interleukin-10 promoter and the risk of human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis in Brazilian individuals
dc.typeArticle


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