The Role of Extracellular Vesicles from Human Macrophages on Host-Pathogen Interaction

dc.creatorArteaga-Blanco, Luis A.
dc.creatorBou-Habib, Dumith Chequer
dc.date2021-11-18T20:48:40Z
dc.date2021-11-18T20:48:40Z
dc.date2021
dc.date.accessioned2023-09-26T22:46:34Z
dc.date.available2023-09-26T22:46:34Z
dc.identifierARTEAGA-BLANCO, Luis A. ; BOU-HABIB, Dumith Chequer. The Role of Extracellular Vesicles from Human Macrophages on Host-Pathogen Interaction. International Journal of Molecular Sciences, v. 22, 10262, p. 1-19, Sept. 2021.
dc.identifier1422-0067
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/49879
dc.identifier10.3390/ ijms221910262
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8883052
dc.descriptionThe nano-sized membrane enclosed extracellular vesicles (EVs) released by virtually all cell types play an essential role in intercellular communication via delivering bio-molecules, such as nucleic acids, proteins, lipids, and other molecules to recipient cells. By mediating an active and steady-state cell-to-cell communication, EVs contribute to regulating and preserving cellular homeostasis. On the other hand, EVs can also spread pathogen-derived molecules during infections, subverting the host immune responses during infections and thus worsening pathophysiological processes. In recent years, the biological functioning of EVs has become a widespread research field in basic and clinical branches of medical sciences due to their potential role in therapeutic applications for several diseases. This review aims to summarize the main recent findings regarding the implication of EVs shed by human macrophages (MF-EVs) and how they can modulate the host immune response to control or increase the damage caused by infectious agents. We will also present the methods used to describe MF-EVs, as well as the potential of these EVs as disease diagnostic tools for some human pathogens. We believe that an in-depth understanding of the host–pathogen interactions mediated by MF-EVs may trigger the development of innovative therapeutic strategies against infectious diseases.
dc.formatapplication/pdf
dc.languageeng
dc.publisherMDPI
dc.rightsopen access
dc.subjectVesículas extracelulares
dc.subjectMacrófagos humanos
dc.subjectImunidade inata
dc.subjectInteração hospedeiro-patógeno e doenças infecciosas
dc.subjectExtracellular vesicles
dc.subjectHuman macrophages
dc.subjectInnate immunity
dc.subjectHost–pathogen interaction and infectious diseases
dc.titleThe Role of Extracellular Vesicles from Human Macrophages on Host-Pathogen Interaction
dc.typeArticle


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