Infusion of autologous bone marrow mononuclear cells through hepatic artery results in a short-term improvement of liver function in patients with chronic liver disease: a pilot randomized controlled study.

dc.creatorLyra, Andre Castro
dc.creatorSoares, Milena Botelho Pereira
dc.creatorSilva, Luiz Flavio Maia da
dc.creatorBraga, Eduardo Lorens
dc.creatorOliveira, Sheilla Andrade de
dc.creatorFortes, Marcos Fraga
dc.creatorSilva, André Goyanna Pinheiro
dc.creatorBrustolim, Daniele
dc.creatorGenser, Bernd
dc.creatorSantos, Ricardo Ribeiro dos
dc.creatorLyra, Luiz Guilherme Costa
dc.date2014-11-27T19:40:51Z
dc.date2014-11-27T19:40:51Z
dc.date2010
dc.date.accessioned2023-09-26T22:46:16Z
dc.date.available2023-09-26T22:46:16Z
dc.identifierLYRA, A. C. et al. Infusion of autologous bone marrow mononuclear cells through hepatic artery results in a short-term improvement of liver function in patients with chronic liver disease: a pilot randomized controlled study. European Journal of Gastroenterology & Hepatology, v. 22, n. 1, p. 33-42, 2010
dc.identifier1473-5687
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/8988
dc.identifier10.1097/MEG.0b013e32832eb69a
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8882989
dc.descriptionAIM: This randomized controlled study evaluated the effect of autologous infusion of bone marrow cells (BMC) in patients with hepatic cirrhosis. METHODS: Thirty patients on the liver transplant waiting list were randomly assigned to receive BMC therapy or no treatment. They were followed up for 1 year. The study was nonblinded. Autologous mononuclear-enriched BMC were infused into the hepatic artery; liver function scores/tests were chosen as endpoints to assess efficacy. Statistical analysis calculated mean relative changes (RC) from baseline and fitted a random-effects model. RESULTS: Mean age, baseline model for end-stage liver disease, and Child-Pugh score were similar in both groups. Child-Pugh score improved in the first 90 days in the cell therapy group compared with controls (P = 0.017, BMC group RC = -8%, controls RC = +5%). The model for end-stage liver disease score remained stable in the treated patients (RC -2 to +6%), whereas it increased during follow-up in the control group (RC +6 to +18%). Albumin levels improved in the treatment arm, whereas they remained stable among controls in the first 90 days (P = 0.034; BMC group RC = +16%, control group RC = +2%). Bilirubin levels increased among controls, whereas they decreased in the therapy arm during the first 60 days; INR RC differences between groups reached up to 10%. The changes observed did not persist beyond 90 days. CONCLUSION: Transplantation of autologous BMC into the hepatic artery improved liver function in patients with advanced cirrhosis in the first 90 days. However, larger studies are necessary to define the role of BMC therapy in cirrhotic patients. Repeated autologous BMC infusions or combination therapy with granulocyte-colony-stimulating factor might improve or sustain the treatment response.
dc.formatapplication/pdf
dc.languageeng
dc.publisherLippincott Williams & Wilkins
dc.rightsopen access
dc.subjectBone marrow stem cell transplantation
dc.subjectCD34+
dc.subjectCell therapy
dc.subjectChronic liver disease
dc.subjectCirrhosis
dc.subjectTransplante de Medula Óssea/métodos
dc.subjectCirrose Hepática/terapia
dc.subjectAdolescente
dc.subjectAdulto
dc.subjectIdoso
dc.subjectBilirrubina/sangue
dc.subjectDoença Crônica
dc.subjectMétodos Epidemiológicos
dc.subjectFeminino
dc.subjectArtéria Hepática
dc.subjectHumanos
dc.subjectCirrose Hepática/sangue
dc.subjectTransplante de Fígado
dc.subjectMasculino
dc.subjectMeia-Idade
dc.subjectTempo de Protrombina
dc.subjectAlbumina Sérica/metabolismo
dc.subjectListas de Espera
dc.subjectAdulto Jovem
dc.titleInfusion of autologous bone marrow mononuclear cells through hepatic artery results in a short-term improvement of liver function in patients with chronic liver disease: a pilot randomized controlled study.
dc.typeArticle


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