Type I Interferon Suppresses Type II Interferon–Triggered Human Anti-Mycobacterial Responses

dc.creatorTeles, Rosane M. B.
dc.creatorGraeber, Thomas G.
dc.creatorKrutzik, Stephan R.
dc.creatorMontoya, Dennis
dc.creatorSchenk, Mirjam
dc.creatorLee, Delphine J.
dc.creatorKomisopoulou, Evangelia
dc.creatorKelly-Scumpia, Kindra
dc.creatorChun, Rene
dc.creatorIyer, Shankar S.
dc.creatorSarno, Euzenir Nunes
dc.creatorRea, Thomas H.
dc.creatorHewison, Martin
dc.creatorAdams, John S.
dc.creatorPopper, Stephen J.
dc.creatorRelman, David A.
dc.creatorStenger, Steffen
dc.creatorBloom, Barry R.
dc.creatorCheng, Genhong
dc.creatorModlin, Robert L.
dc.date2016-01-21T14:06:52Z
dc.date2016-01-21T14:06:52Z
dc.date2013
dc.date.accessioned2023-09-26T22:46:00Z
dc.date.available2023-09-26T22:46:00Z
dc.identifierTELES, Rosane M. B. et al. Type I Interferon Suppresses Type II Interferon–Triggered Human Anti-Mycobacterial Responses. Science, v.339, p.1448-1453, March 2013.
dc.identifier1095-9203
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/12579
dc.identifier10.1126/science.1233665
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8882935
dc.descriptionType I interferons (IFN-a and IFN-b) are important for protection against many viral infections, whereas type II interferon (IFN-g) is essential for host defense against some bacterial and parasitic pathogens. Study of IFN responses in human leprosy revealed an inverse correlation between IFN-b and IFN-g gene expression programs. IFN-g and its downstream vitamin D–dependent antimicrobial genes were preferentially expressed in self-healing tuberculoid lesions and mediated antimicrobial activity against the pathogen Mycobacterium leprae in vitro. In contrast, IFN-b and its downstream genes, including interleukin-10 (IL-10), were induced in monocytes by M. leprae in vitro and preferentially expressed in disseminated and progressive lepromatous lesions. The IFN-g–induced macrophage vitamin D–dependent antimicrobial peptide response was inhibited by IFN-b and by IL-10, suggesting that the differential production of IFNs contributes to protection versus pathogenesis in some human bacterial infections.
dc.formatapplication/pdf
dc.languageeng
dc.publisherAmerican Association for the Advancement of Science
dc.rightsopen access
dc.subjectType I interferons (IFN-a and IFN-b)
dc.subjecttype II interferon (IFN-g)
dc.subjectLeprosy
dc.subjectAnti-Mycobacterial
dc.subjectMycobacterium leprae
dc.subjectMycobacterium leprae
dc.subjectHanseniase
dc.subjectInterferon Tipo I
dc.subjectInterferon gama
dc.titleType I Interferon Suppresses Type II Interferon–Triggered Human Anti-Mycobacterial Responses
dc.typeArticle


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