Depressive symptoms increase the risk of progression to dementia in subjects with mild cognitive impairment: systematic review and meta-analysis.

dc.creatorMourao, Raimundo Jorge Serra Duarte Vaz
dc.creatorMansur, Guilherme
dc.creatorDiniz, Leandro Fernandes Malloy
dc.creatorCosta, Erico Castro
dc.creatorDiniz, Breno Satler
dc.date2018-06-11T18:24:43Z
dc.date2018-06-11T18:24:43Z
dc.date2015
dc.date.accessioned2023-09-26T22:45:53Z
dc.date.available2023-09-26T22:45:53Z
dc.identifierMOURÃO, Raimundo Jorge Serra Duarte Vaz et al. Depressive symptoms increase the risk of progression to dementia in subjects with mild cognitive impairment: systematic review and meta-analysis. Int. j. geriat. Psychiatry., v. 31, n. 8, p. 905-911, 2015
dc.identifier1099-1166
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/26810
dc.identifier10.1002/gps.4406
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8882911
dc.descriptionObjective: There is a long-standing debate in the literature whether depressive symptoms increase the risk of dementia in older with mild cognitive impairment (MCI). We aim to conduct a meta-analysis of studies that evaluated the risk of dementia in subjects with MCI and depressive symptoms compared with subjects with MCI and no depressive symptoms. Methods: We calculated the relative risk of progression to dementia in subjects with MCI and depressive symptoms compared with subjects with MCI and no depressive symptoms using a generic inverse variance method with random effect models. Results: Eighteen studieswere includedin themeta-analysis,with a sample size of 10,861MCI subjects. The pooled relative risk of progressing to dementia was 1.28 CI95% [1.09–1.52] (p= 0.003) in the group of MCI subjects with depressive symptoms compared with the MCI subjects with no depressive symptoms. Discussion: Our results provide additional evidence that depressive symptoms determine an additive risk effect to the progression to dementia in subjects with MCI. The comorbidity between depression and cognitive impairment can be an intervention target for prevention of dementia in MCI subjects.
dc.description2050-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherWiley & Sons, Ltd.
dc.rightsrestricted access
dc.subjectdepressão
dc.subjectdemencia
dc.subjectdepression
dc.subjectmild cognitive impairment
dc.subjectdementia
dc.subjectAlzheimer’s disease
dc.titleDepressive symptoms increase the risk of progression to dementia in subjects with mild cognitive impairment: systematic review and meta-analysis.
dc.typeArticle


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