High expression of co-stimulatory and adhesion molecules are observed on eosinophils during human Schistosoma mansoni infection

dc.creatorLemos, Denise da Silveira
dc.creatorCarvalho, Andréa Teixeira
dc.creatorMartins Filho, Olindo Assis
dc.creatorOliveira, Lúcia Fraga Alves
dc.creatorOliveira, Rodrigo Corrêa de
dc.date2013-06-12T18:33:20Z
dc.date2013-06-12T18:33:20Z
dc.date2006
dc.date.accessioned2023-09-26T22:44:58Z
dc.date.available2023-09-26T22:44:58Z
dc.identifierSILVEIRA-LEMOS, Denise et al. High expression of co-stimulatory and adhesion molecules are observed on eosinophils during human Schistosoma mansoni infection. Mem. Inst. Oswaldo Cruz . 2006, vol.101, suppl.1, pp. 345-351
dc.identifier0074-0276
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/6583
dc.identifierorg/10.1590/S0074-02762006000900056
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8882717
dc.descriptionCPqRR/Fiocruz, CNPq, National Institutes of Health (PA- 98-078)
dc.descriptionHere in we have focused attention on major phenotypic features of peripheral blood eosinophils from chronic Schistosoma mansoni-infected patients. For this purpose, detailed immunophenotypic profiles of a range of cell surface markers were performed, including activation markers (CD23/CD69/CD25/HLA-DR), co-stimulatory mol-ecules (CD28/CD80/CD86), chemokine receptors (CXCR1/CXCR2/CCR3/CCR5) besides L-selectin-CD62L and adhesion molecules (CD18/CD54). Our major findings pointed out increased frequency of CD23 + -cells, besides decreased percentages of CD69 + -eosinophils, suggesting a chronic activation status with low frequency of early activated eosinophils in chronic S. mansoni-infected patients (INT) in comparison to non-infected individuals (NI). Moreover, a dichotomic expression of beta-chemokine receptors was observed during human schistosomiasis mansoni with higher CCR5 and lower levels of CCR3 observed between groups. Enhanced expression of co-stimulatory receptors (CD28/CD86) and adhesion molecules (CD54/CD18), besides striking lower frequency of L-selectin + were reported for eosinophils from INT group as compared to NI. Interestingly, the frequency of CD62L+ -eosinophils and a range of cell activation related molecules pointed out an opposite pattern of association in NI and INT, where only INT patients that display lower frequency of CD62L + -eosinophils (first CD62L tertile) kept the unusual rela-tionship between the expression of L-selectin and the CD23 activation marker. These findings suggest that distinct dynamic of activation markers expressed by eosinophils may occur during chronic S. mansoni infection.
dc.formatapplication/pdf
dc.languageeng
dc.rightsopen access
dc.subjectSchistosomiasis
dc.subjectEosinophils
dc.subjectActivation markers
dc.subjectL-selectin
dc.titleHigh expression of co-stimulatory and adhesion molecules are observed on eosinophils during human Schistosoma mansoni infection
dc.typeArticle


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