dc.creatorSilva-Filha, Maria Helena Neves Lobo
dc.creatorRomão, Tatiany Patricia
dc.creatorRezende, Tatiana Maria Teodoro
dc.creatorCarvalho, Karine da Silva
dc.creatorGouveia de Menezes, Heverly Suzany
dc.creatorAlexandre do Nascimento, Nathaly
dc.creatorSoberón, Mario
dc.creatorBravo, Alejandra
dc.date2022-02-15T11:32:24Z
dc.date2022-02-15T11:32:24Z
dc.date2021
dc.date.accessioned2023-09-26T22:44:53Z
dc.date.available2023-09-26T22:44:53Z
dc.identifierSILVA-FILHA, Maria Helena Neves Lobo et al. Bacterial Toxins Active against Mosquitoes: Mode of Action and Resistance. Toxins, v. 13, p. 1-37, 2021.
dc.identifier2072-6651
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/51193
dc.identifier10.3390/toxins13080523
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8882698
dc.descriptionLarvicides based on the bacteria Bacillus thuringiensis svar. israelensis (Bti) and Lysinibacillus sphaericus are effective and environmentally safe compounds for the control of dipteran insects of medical importance. They produce crystals that display specific and potent insecticidal activity against larvae. Bti crystals are composed of multiple protoxins: three from the three-domain Cry type family, which bind to different cell receptors in the midgut, and one cytolytic (Cyt1Aa) protoxin that can insert itself into the cell membrane and act as surrogate receptor of the Cry toxins. Together, those toxins display a complex mode of action that shows a low risk of resistance selection. L. sphaericus crystals contain one major binary toxin that display an outstanding persistence in field conditions, which is superior to Bti. However, the action of the Bin toxin based on its interaction with a single receptor is vulnerable for resistance selection in insects. In this review we present the most recent data on the mode of action and synergism of these toxins, resistance issues, and examples of their use worldwide. Data reported in recent years improved our understanding of the mechanism of action of these toxins, showed that their combined use can enhance their activity and counteract resistance, and reinforced their relevance for mosquito control programs in the future years.
dc.formatapplication/pdf
dc.languagepor
dc.rightsopen access
dc.subjectBacterial Toxins
dc.subjecttoxicity
dc.subjectMosquito Control
dc.subjectmethods
dc.subjectPest Control, Biological
dc.subjectmethods
dc.subjectAnimals
dc.subjectBacillaceae
dc.subjectBacillus thuringiensis
dc.subjectCulicidae
dc.subjectBti
dc.subjectLysinibacillus sphaericus
dc.subjectCry toxin
dc.subjectCyt toxin
dc.subjectBinary toxin
dc.subjectReceptors
dc.titleBacterial Toxins Active against Mosquitoes: Mode of Action and Resistance
dc.typeArticle


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