Hepatic gluconeogenesis in rats trained to eat a single meal daily. Role of eating periodicity and the amount of food ingested in the last meal

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorBatista, Márcia R.
dc.creatorVasconcelos, Márcio S.
dc.creatorRebola, Vinícius D.
dc.creatorGalletto, Ricardo
dc.creatorCuri, Rui
dc.creatorBazotte, Roberto B.
dc.date2014-05-27T11:20:22Z
dc.date2016-10-25T18:17:29Z
dc.date2014-05-27T11:20:22Z
dc.date2016-10-25T18:17:29Z
dc.date2001-12-01
dc.date.accessioned2017-04-06T01:01:20Z
dc.date.available2017-04-06T01:01:20Z
dc.identifierResearch Communications in Molecular Pathology and Pharmacology, v. 109, n. 5-6, p. 345-356, 2001.
dc.identifier1078-0297
dc.identifierhttp://hdl.handle.net/11449/66743
dc.identifierhttp://acervodigital.unesp.br/handle/11449/66743
dc.identifier2-s2.0-0042371960
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/888267
dc.descriptionRats trained to eat a single daily meal (MF rats), from 8:00-10:00 a.m., increased food intake from the 1 st to the 12 th (125%) day of feeding training. In this work we compared the influence of the higher food ingestion in the last meal and feeding training on hepatic gluconeogenesis. Thus, rats at the 1 st (MF 1st day-5g group) and 13 th day (MF 13th day-5g group) of training, refed with a fixed amount of food (5g) were employed. In addition, a third group of MF rats, refed on day 12 with 75% (12g) of the food ingested by MF rats on the 13 th day of the feeding training (MF 13th day-12g) was included. The experiments were performed at 22 h after meal (8:00 a.m.). Our results demonstrated that feeding training had a crucial role in determining gluconeogenesis from pyruvate (5 mM). Additionally, gluconeogenesis from L-glutamine (5 mM) was influenced by periodicity of eating and the amount of food ingested in the last meal. In contrast, gluconeogenesis from L-alanine (5 mM) was not influenced by both factors. In conclusion, our findings suggested that the hepatic gluconeogenesis was influenced by food ingestion and/or feeding training depending of the substrate investigated. These effects on gluconeogenesis may have implications for use in diabetic regimens.
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageeng
dc.relationResearch Communications in Molecular Pathology and Pharmacology
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectEating schedules
dc.subjectFeeding training
dc.subjectFood intake
dc.subjectGluconeogenesis
dc.subjectImplications in diabetes
dc.subjectL-glutamine and L-alanine and gluconeogenesis
dc.subjectPeriodicity of eating
dc.subjectalanine
dc.subjectglutamine
dc.subjectpyruvic acid
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectcontrolled study
dc.subjectdiabetic diet
dc.subjectfeeding
dc.subjectfood intake
dc.subjectgluconeogenesis
dc.subjectliver metabolism
dc.subjectmale
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectrat
dc.subjectAdaptation, Physiological
dc.subjectAnimals
dc.subjectBlood Glucose
dc.subjectEating
dc.subjectGlucose
dc.subjectLactates
dc.subjectLiver
dc.subjectLiver Glycogen
dc.subjectMale
dc.subjectPeriodicity
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectUrea
dc.titleHepatic gluconeogenesis in rats trained to eat a single meal daily. Role of eating periodicity and the amount of food ingested in the last meal
dc.typeOtro


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