Extrathymic CD4+CD8+ lymphocytes in Chagas disease: possible relationship with an immunoendocrine imbalance

dc.creatorPérez, Ana R.
dc.creatorMorrot, Alexandre
dc.creatorBerbert, Luiz R.
dc.creatorTerra-Granado, Eugenia
dc.creatorSavino, Wilson
dc.date2017-04-20T16:28:44Z
dc.date2017-04-20T16:28:44Z
dc.date2012
dc.date.accessioned2023-09-26T22:44:08Z
dc.date.available2023-09-26T22:44:08Z
dc.identifierPÈREZ, Ana R. et al. Extrathymic CD4+CD8+ lymphocytes in Chagas disease: possible relationship with an immunoendocrine imbalance. Ann. N.Y. Acad. Sci., v.1262, p.27–36, 2012.
dc.identifier0077-8923
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/18599
dc.identifier10.1111/j.1749-6632.2012.06627.x
dc.identifier1749-6632
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8882543
dc.descriptionDouble-positive (DP) CD4(+) CD8(+) T cells normally represent a thymic subpopulation that is developed in the thymus as a precursor of CD4(+) or CD8(+) single-positive T cells. Recent evidence has shown that DP cells with an activated phenotype can be tracked in secondary lymph organs. The detection of an activated DP population in the periphery, a population that expresses T cell receptors unselected during thymic negative selection in murine models of Trypanosoma cruzi infection and in humans with Chagas disease, raise new questions about the relevance of this population in the pathogenesis of this major parasitic disease and its possible link with immunoendocrine alterations.
dc.description2030-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherWiley
dc.rightsrestricted access
dc.subjectDoença de Chagas
dc.subjectinfecção por Trypanosoma cruzi
dc.subjectidrocortisona
dc.subjectDesidroepiandrosterona
dc.subjectTimo
dc.subjectRelação CD4-CD8
dc.subjectCD4+CD8+ double-positive CD4+CD8+ T cell
dc.subjectthymus
dc.subjectChagas Disease
dc.subjectTrypanosoma cruzi infection
dc.subjectcortisol
dc.subjectdehydroepiandrosterone
dc.titleExtrathymic CD4+CD8+ lymphocytes in Chagas disease: possible relationship with an immunoendocrine imbalance
dc.typeArticle


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