Histopathologic features associated with susceptibility and resistance of Biomphalaria snails to infection with Schistosoma mansoni

dc.creatorBorges, Claudia Maria da Cunha
dc.creatorSouza, Cecília Pereira de
dc.creatorAndrade, Zilton de Araújo
dc.date2012-10-15T19:09:17Z
dc.date2012-10-15T19:09:17Z
dc.date1998
dc.date.accessioned2023-09-26T22:44:08Z
dc.date.available2023-09-26T22:44:08Z
dc.identifierBORGES, C.M.; de SOUZA, C.P.; ANDRADE, Z.A. Histopathologic features associated with susceptibility and resistance of Biomphalaria snails to infection with Schistosoma mansoni. Memórias do Instituto Oswaldo Cruz, v. 93, Suppl 1, p. 117-21, 1998.
dc.identifier0074-0276
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/5664
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8882542
dc.descriptionResistance and susceptibility of Biomphalaria snails to Schistosoma mansoni sporocysts occur in different degrees. Histopathology reflects these differences. In a state of tolerance numerous sporocysts in different stages of differentiation are seen in the absence of host tissue reaction. However extensive diffuse and focal proliferation of amebocytes with sequestration and destruction of many parasitic structures appear in resistant snails. Some snails are totally resistant and when exposed to infecting miracidia may never eliminate cercarie. Sequential histopathological examination has revealed that in such cases the infected miracidia are destroyed a few minutes to 24 hr after penetration in the snail. However, B. glabrata that were exposed to S. mansoni miracidia and three months later failed to shed cercariae, exhibited focal and diffuse proliferation of amebocytes in many organs in the absence of pasitic structures. These lesions were similar to those observed in resistant snails that were still eliminating a few cercariae, with the difference that no recognizable sporocystic structures or remnants were present. Histological investigation carried out in similarly resistant B. tenagophila and B. straminea presented essentially normal histologic structures. Only occasionally a few focal proliferative (granulomatous) amebocytic reactions were seen in ovotestis and in the tubular portion of the kidney. Probably, there are two types of reactions to miracidium presented by totally resistant snails: one would implicate the immediate destruction of the miracidium leaving no traces in the tissues; the other involving late reactions that seem to completely destroy invading sporocysts and leave histological changes.
dc.formatapplication/pdf
dc.languageeng
dc.rightsopen access
dc.subjectSnails
dc.subjectSchistosoma mansoni -
dc.subjectSusceptibility
dc.subjectResistance
dc.subjectHistopathology
dc.subjectBiomphalaria/parasitologia
dc.subjectSchistosoma mansoni/patogenicidade
dc.subjectAnimais
dc.subjectBiomphalaria/fisiologia
dc.subjectInterações Hospedeiro-Parasita/fisiologia
dc.titleHistopathologic features associated with susceptibility and resistance of Biomphalaria snails to infection with Schistosoma mansoni
dc.typeArticle


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