Effect of early brain infarction after subarachnoid hemorrhage: a systematic review and meta-analysis

dc.creatorGonçalves, Bruno
dc.creatorTuron, Ricardo
dc.creatorMendes, Antenor
dc.creatorMelo, Nivea
dc.creatorLacerda, Paula
dc.creatorBrasil, Pedro
dc.creatorBozza, Fernando Augusto
dc.creatorKurtz, Pedro
dc.creatorRighy, Cassia
dc.date2019-07-01T12:26:52Z
dc.date2019-07-01T12:26:52Z
dc.date2018
dc.date.accessioned2023-09-26T22:43:52Z
dc.date.available2023-09-26T22:43:52Z
dc.identifierGONÇALVES, Bruno et al. Effect of early brain infarction after subarachnoid hemorrhage: a systematic review and meta-analysis. World Neurosurgery, v. 115, p. 292-298, July 2018.
dc.identifier1878-8750
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/33742
dc.identifier10.1016/j.wneu.2018.04.037
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8882489
dc.descriptionOBJECTIVE: Aneurysmal subarachnoid hemorrhage (aSAH) is an acute cerebrovascular event that leads to devastating consequences. Early brain infarction (EBI) develops very early, within the first 72 hours after bleeding, and may have a significant impact on long-term outcomes. The incidence andimpact of EBI in the prognosis of aSAH remain uncertain. We performed a systematic review and meta-analysis to evaluatethe incidence of EBI in patients with aSAH and determine its effect on mortality and functional outcomes. METHODS: We performed a systematic review and meta-analysis. Inclusion criteria were 1) studies that evaluated aSAH within 72 hours after bleeding; 2) performed a brain imaging study up to 72 hours of hemorrhage; 3) used computed tomography or magnetic resonance imaging; and 4) included a description of the findings of the brain imaging study (whether or not an infarct was present). RESULTS: Ten studies that met the criteria were included. The incidence of EBI was 17%. The risk ratio for 3-month mortality was 2.18 (95% confidence interval 1.48-3.30). The overall risk ratio for poor outcome was 2.26 (95% confidence interval 1.75-2.93). CONCLUSIONS: EBI plays an important role in the outcome of patients with aSAH. Its significant impact couldrepresent a new therapeutic frontier for improving outcomesof these patients.
dc.description2026-12-31
dc.formatapplication/pdf
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsrestricted access
dc.subjectBrain infarction
dc.subjectBrain injuries
dc.subjectBrain ischemia
dc.subjectSubarachnoid hemorrhage
dc.subjectSubarachnoid hemorrhage outcomes
dc.titleEffect of early brain infarction after subarachnoid hemorrhage: a systematic review and meta-analysis
dc.typeArticle


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