Humoral and cellular immune responses in BALB/c and C57BL/6 mice immunized with cytoplasmic (CRA) and flagellar (FRA) recombinant repetitive antigens, in acute experimental Trypanosoma cruzi infection.

dc.creatorPereira, Valéria Rêgo Alves
dc.creatorLorena, Virginia Maria Barros de
dc.creatorNakazawa, Mineo
dc.creatorLuna, Carlos Feitosa
dc.creatorSilva, Edimilson Domingos da
dc.creatorFerreira, Antonio Gomes Pinto
dc.creatorKrieger, Marco Aurélio
dc.creatorGoldenberg, Samuel
dc.creatorSoares, Milena Botelho Pereira
dc.creatorCoutinho, Eridan de Medeiros
dc.creatorOliveira, Rodrigo Corrêa
dc.creatorGomes, Yara de Miranda
dc.date2015-04-14T17:25:18Z
dc.date2015-04-14T17:25:18Z
dc.date2005
dc.date.accessioned2023-09-26T22:43:32Z
dc.date.available2023-09-26T22:43:32Z
dc.identifierPEREIRA, V. R. A. et al. Humoral and cellular immune responses in BALB/c and C57BL/6 mice immunized with cytoplasmic (CRA) and flagellar (FRA) recombinant repetitive antigens, in acute experimental Trypanosoma cruzi infection. Parasitology Research, v. 96, n. 3, p. 154-161, 2005.
dc.identifier0932-0113
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/9993
dc.identifier10.1007/s00436-005-1336-4
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8882418
dc.descriptionIn previous studies, cytoplasmic repetitive antigen (CRA) and flagellar repetitive antigen (FRA) proteins induced specific humoral and cellular immune responses in susceptible and resistant mice in the absence of Trypanosoma cruzi infection with a significant induction of the Interferon-gamma (IFN-gamma) production in those animals. In this follow-up paper, the immunostimulatory and protective effects of these proteins were evaluated by immunizing with CRA or FRA antigens, BALB/c and C57BL/6 mice and challenging with a T. cruzi (Y strain). Both proteins induced humoral response with high levels of IgG isotypes as well as cellular immunity with high levels of IFN-gamma when compared to controls. However, the lymphocyte proliferative response was minimal. The survival rate at 30 days post-infection was significant in CRA (60%) or FRA (50%)--immunized BALB/c mice and CRA (83.3%)--immunized C57BL/6 mice. Taken as a whole these findings indicate that CRA and FRA are immunogenic and potentially important for protective immunity.
dc.formatapplication/pdf
dc.languageeng
dc.publisherSpringer Verlag
dc.rightsopen access
dc.subjectAnticorpos Antiprotozoários/sangue
dc.subjectAntígenos de Protozoários/imunologia
dc.subjectDoença de Chagas/imunologia
dc.subjectProteínas Recombinantes/imunologia
dc.subjectTrypanosoma cruzi/imunologia
dc.subjectAnimais
dc.subjectAntígenos de Protozoários/administração & dosagem
dc.subjectModelos Animais de Doenças
dc.subjectEnsaio de Imunoadsorção Enzimática
dc.subjectImunidade Celular
dc.subjectImunoglobulina G/sangue
dc.subjectInterferon gama/análise
dc.subjectLinfócitos/imunologia
dc.subjectMasculino
dc.subjectCamundongos
dc.subjectCamundongos Endogâmicos BALB C
dc.titleHumoral and cellular immune responses in BALB/c and C57BL/6 mice immunized with cytoplasmic (CRA) and flagellar (FRA) recombinant repetitive antigens, in acute experimental Trypanosoma cruzi infection.
dc.typeArticle


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