Clinical features and genetic background of the sympatric species Paracoccidioides brasiliensis and Paracoccidioides americana

dc.creatorMacedo, Priscila Marques de
dc.creatorTeixeira, Marcus de Melo
dc.creatorBarker, Bridget M.
dc.creatorZancopé-Oliveira, Rosely Maria
dc.creatorAlmeida-Paes, Rodrigo
dc.creatorValle, Antonio Carlos Francesconi do
dc.date2019-06-04T13:30:37Z
dc.date2019-06-04T13:30:37Z
dc.date2019
dc.date.accessioned2023-09-26T22:43:18Z
dc.date.available2023-09-26T22:43:18Z
dc.identifierMACEDO, Priscila Marques de et al. Clinical features and genetic background of the sympatric species Paracoccidioides brasiliensis and Paracoccidioides americana. Plos Neglected Tropical Diseases, v. 13, n. 4, p. 1-20, Apr. 2019.
dc.identifier1935-2727
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/33357
dc.identifier10.1371/journal.pntd.0007309
dc.identifier1935-2735
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8882366
dc.descriptionIntroduction: The agents of paracoccidioidomycosis, historically identified as Paracoccidioides brasiliensis, are in fact different phylogenetic species. This study aims to evaluate associations between Paracoccidioides phylogenetic species and corresponding clinical data. Methods: Paracoccidioides strains from INI/Fiocruz patients (1998–2016) were recovered. Sociodemographic, epidemiological, clinical, serological, therapeutic and prognostic data of the patients were collected to evaluate possible associations of these variables with the fungal species identified through partial sequencing of the ADP-ribosylation factor (arf) and the 43- kDa-glycoprotein (gp43) genes. Results: Fifty-four fungal strains were recovered from 47 patients, most (72.3%) infected in Rio de Janeiro state, Brazil. Forty-one cases were caused by Paracoccidioides brasiliensis and six by Paracoccidioides americana (former PS2). P. brasiliensis was responsible for severe lymph abdominal forms, whereas patients infected with P. americana presented a high rate of adrenal involvement. However, no statistically significant associations were found for all variables studied. P. americana presented 100% reactivity to immunodiffusion, even when tested against antigens from other species, while negative results were observed in 9 (20%) cases caused by P. brasiliensis, despite being tested against a homologous antigen. Conclusions: P. brasiliensis and P. americana are sympatric and share similar clinical features and habitat, where they may compete for similar hosts.
dc.formatapplication/pdf
dc.languageeng
dc.publisherPublic Library of Science
dc.rightsopen access
dc.subjectParacoccidioidomycosis
dc.subjectParacoccidioides brasiliensis
dc.subjectParacoccidioides americana
dc.titleClinical features and genetic background of the sympatric species Paracoccidioides brasiliensis and Paracoccidioides americana
dc.typeArticle


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