A molecular study on the evolution of a subtype B variant frequently found in Brazil

dc.creatorPinto, M. E.
dc.creatorSchrago, C. G.
dc.creatorMiranda, A. B.
dc.creatorRusso, C. A. M.
dc.date2019-03-12T17:07:43Z
dc.date2019-03-12T17:07:43Z
dc.date2008
dc.date.accessioned2023-09-26T22:43:04Z
dc.date.available2023-09-26T22:43:04Z
dc.identifierPINTO, M. E. et al. A molecular study on the evolution of a subtype B variant frequently found in Brazil. Genetics and Molecular Research, v. 7, n. 4, p. 1031-1044, 2008.
dc.identifier1676-5680
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/32048
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8882316
dc.descriptionIn spite of the remarkable diversity of HIV-1 env genes, several amino acids are extremely conserved, probably due to functional constraints. One example is the proline found at the second position of the GPGR motif. Several viruses, however, bear substitutions at this site, for instance, GWGR subtype B variant. GWGR viruses are described in Brazil since the beginning of the epidemics, but the extent of their dispersion or the geographical origin of the variant remains unknown. In the present study, phylogenetic trees were constructed in order to study the origin and spread of this variant. All GWGR sequences as well as a subset of subtype B sequences available were included in the analyses. Analyses of differential selection were also performed on GWGR and non-GWGR sequences in order to unveil evolutionary novelties due to the action of positive selection. Although the GWGR variant was found at least in 23 countries, its expansion probably has a single origin, and Brazil is the epicenter.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFUNPEC-RP
dc.rightsopen access
dc.subjectHIV-1
dc.subjectSubtipo B
dc.subjectEvolução molecular
dc.subjectOrigem
dc.subjectVariante GWGR
dc.subjectPressão seletiva
dc.subjectBrasil
dc.subjectHIV-1
dc.subjectSubtype B
dc.subjectGWGR variant
dc.subjectMolecular evolution
dc.subjectOrigin
dc.subjectSelective pressure
dc.subjectBrazil
dc.titleA molecular study on the evolution of a subtype B variant frequently found in Brazil
dc.typeArticle


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