Maternal schistosomiasis alters costimulatory molecules expression in antigen-presenting cells from adult offspring mice

dc.creatorSantos, Patrícia d'Emery Alves
dc.creatorLorena, Virgínia Maria Barros
dc.creatorFernandes, Érica
dc.creatorSales, Iana Rafaela Fernandes
dc.creatorAlbuquerque, Mônica Camelo Pessoa
dc.creatorGomes, Yara
dc.creatorCosta, Vlaudia Maria Assis
dc.creatorSouza, Valdênia Maria Oliveira
dc.date2017-11-27T14:31:44Z
dc.date2017-11-27T14:31:44Z
dc.date2014
dc.date.accessioned2023-09-26T22:42:58Z
dc.date.available2023-09-26T22:42:58Z
dc.identifierSANTOS, P. D’EMERY A. et al. Maternal schistosomiasis alters costimulatory molecules expression in antigen-presenting cells from adult offspring mice. Experimental Parasitology, v. 141, p. 62–67, jun. 2014.
dc.identifier1090-2449
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/23368
dc.identifier10.1016/j.exppara.2014.03.017
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8882296
dc.descriptionAdult offspring of Schistosoma mansoni-infected mice showed alterations in immunity to a heterologous antigen, ovalbumin (OA). Prior breastfeeding induced increased production of anti-OA antibodies, while pregnancy impaired it. Here, we investigated the expression of costimulatory molecules on antigen-presenting cells (APCs) of the adult offspring of S. mansoni-infected mothers in response to OA. Newborn mice were divided into three groups: animals Born Infected Mothers (BIM) suckled by non-infected mothers; animals from non-infected mothers Suckled Infected Mothers (SIM); and another group of mice born from and suckled by non-infected mothers (CONTROL). The adult offspring were immunized with subcutaneous OA+adjuvant, and 3-8days following immunization, double labeling was performed (CD45R/B220 or CD11c and CD80, CD86, CD40 or HLA-DR) on spleen cells. In comparison to the CONTROL group, an early increased frequency of CD40+/CD80+ B cells was observed in SIM mice (p<0.001/p<0.05), but no alteration of CD11c+ cells was observed. In contrast, in BIM mice, the frequency of CD86+/CD11c+ cells (p<0.05) and CD40+/CD80+/CD86+ B cells (p<0.01/p<0.01/p<0.05) was drastically reduced. In conclusion, previous suckling by S. mansoni-infected mothers enabled improved antigen presentation by B cells in adult offspring, whereas gestation in these mothers imprinted offspring with weak antigen presentation by APCs during the immune response to a non-related antigen.
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsopen access
dc.subjectCrianças Adultas
dc.subjectAleitamento Materno
dc.subjectMoléculas estimuladoras
dc.subjectGravidez
dc.subjectEsquistossomose materna
dc.subjectAdult offspring
dc.subjectBreastfeeding
dc.subjectCostimulatory molecules
dc.subjectGestation
dc.subjectMaternal schistosomiasis
dc.subjectCélulas Apresentadoras de Antígenos
dc.subjectimunologia
dc.subjectAntígenos CD
dc.subjectmetabolismo
dc.subjectImunidade Materno-Adquirida
dc.subjectComplicações Parasitárias na Gravidez
dc.subjectEsquistossomose mansoni
dc.subjectAnimais
dc.subjectAntígenos CD40
dc.subjectAntígenos CD80
dc.subjectAntígenos CD86
dc.subjectFeminino
dc.subjectTransmissão Vertical de Doença Infecciosa
dc.subjectMasculino
dc.subjectCamundongos
dc.subjectGravidez
dc.subjectEsquistossomose mansoni
dc.subjecttransmissão
dc.titleMaternal schistosomiasis alters costimulatory molecules expression in antigen-presenting cells from adult offspring mice
dc.typeArticle


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