Enterolobin induces rat paw oedema independently of PAF-acether

dc.creatorFaria Neto, H. C. Castro
dc.creatorCordeiro, R. S. B.
dc.creatorMartins, M. A.
dc.creatorSilva, A. C. V. Correira da
dc.creatorBozza, P. T.
dc.creatorSousa, M. V.
dc.creatorMorhy, L.
dc.date2020-09-18T20:08:53Z
dc.date2020-09-18T20:08:53Z
dc.date1991
dc.date.accessioned2023-09-26T22:42:51Z
dc.date.available2023-09-26T22:42:51Z
dc.identifierFARIA NETO, H. C. Castro et al. Enterolobin induces rat paw oedema independently of PAF-acether. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 82, Suppl. 2, p. 129-131, 1991.
dc.identifier0074-0276
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/43467
dc.identifier10.1590/S0074-02761991000600029
dc.identifier1678-8060
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8882268
dc.descriptionThe potential participation of PAF-acether (PAF) on the paw oedema triggered by enterolobin was investigated. Intraplantar injections of enterolobin )5-20 µg/paw) yielded a dose response curve for edema which appeared after 30 min, peaked in the interval between 2-4 h and faded after 24h. The pre-treatment with BN 52021, but not with other PAF antagonists such as PCA 4248 or WEB 2086, significantly blocked enterolobin-induced oedema. To clarify better the discrepant results obtained with the PAF antagonists, desensitization to PAF was performed. The oedema triggered by enterolobin was not modified in paf desensitized animals. It was concluded that the paw inflammation induced by enterolobin does not require PAF mechanism.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFundação Oswaldo Cruz. Instituto Oswaldo Cruz.
dc.rightsopen access
dc.subjectProteínas de toxina
dc.subjectEdema de pata
dc.subjectPAF
dc.subjectToxin proteins
dc.subjectPAF
dc.subjectPaw oedema
dc.titleEnterolobin induces rat paw oedema independently of PAF-acether
dc.typeArticle


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