The Emerging Role of Complement Lectin Pathway in Trypanosomatids: Molecular Bases in Activation, Genetic Deficiencies, Susceptibility to Infection, and Complement System-Based Therapeutics

dc.creatorEvans-Osses, Ingrid
dc.creatorReason, Iara de Messias
dc.creatorRamirez, Marcel I.
dc.date2015-08-19T13:49:31Z
dc.date2015-08-19T13:49:31Z
dc.date2013
dc.date.accessioned2023-09-26T22:42:34Z
dc.date.available2023-09-26T22:42:34Z
dc.identifierEVANS-OSSES, Ingrid; REASON, iara de Messias; RAMIREZ, Marcel I.. The Emerging Role of Complement Lectin Pathway in Trypanosomatids: Molecular Bases in Activation, Genetic Deficiencies, Susceptibility to Infection, and Complement System-Based Therapeutics. The ScientificWorld Journal, Volume 2013, Article ID 675898, 12 pages.
dc.identifier2356-6140
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/11552
dc.identifier10.1155/2013/675898
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8882209
dc.descriptionThe innate immune systemis evolutionary and ancient and is the pivotal line of the host defense systemto protect against invading pathogens and abnormal self-derived components. Cellular and molecular components are involved in recognition and effector mechanisms for a successful innate immune response. The complement lectin pathway (CLP) was discovered in 1990. These new components at the complement world are very efficient. Mannan-binding lectin (MBL) and ficolin not only recognize many molecular patterns of pathogens rapidly to activate complement but also display several strategies to evade innate immunity.Many studies have shown a relation between the deficit of complement factors and susceptibility to infection. The recently discovered CLP was shown to be important in host defense against protozoan microbes. Although the recognition of pathogen-associated molecular patterns by MBL and Ficolins reveal efficient complement activations, an increase in deficiency of complement factors and diversity of parasite strategies of immune evasion demonstrate the unsuccessful effort to control the infection. In the present paper, we will discuss basic aspects of complement activation, the structure of the lectin pathway components, genetic deficiency of complement factors, and new therapeutic opportunities to target the complement system to control infection.
dc.formatapplication/pdf
dc.languageeng
dc.publisherHindawi Publishing Corporation
dc.rightsopen access
dc.subjectTrypanosomatids
dc.subjectComplement Lectin Pathway (CLP)
dc.subjectSystem-Based Therapeutics
dc.subjectProtozoan Parasites
dc.subjectInfectious diseases
dc.subjectTerapêutica
dc.subjectDoenças Transmissíveis
dc.titleThe Emerging Role of Complement Lectin Pathway in Trypanosomatids: Molecular Bases in Activation, Genetic Deficiencies, Susceptibility to Infection, and Complement System-Based Therapeutics
dc.typeArticle


Este ítem pertenece a la siguiente institución