Density of mast cells and microvessels in minor salivary gland tumors

dc.creatorVidal, Manuela Torres Andion
dc.creatorAraújo, Iguaracyra Barreto de Oliveira
dc.creatorGurgel, Clarissa Araújo Silva
dc.creatorPereira, Francisco de Assis Caldas
dc.creatorVilas Boas, Deise Souza
dc.creatorRamos, Eduardo Antônio Gonçalves
dc.creatorAgra, Ivan Marcelo Gonçalves
dc.creatorBarros, Adna Conceição
dc.creatorFreitas, Valéria Souza
dc.creatorSantos, Jean Nunes dos
dc.date2014-11-19T12:59:39Z
dc.date2014-11-19T12:59:39Z
dc.date2013
dc.date.accessioned2023-09-26T22:42:31Z
dc.date.available2023-09-26T22:42:31Z
dc.identifierVIDAL. M. T. A. et al. Density of mast cells and microvessels in minor salivary gland tumors. Tumour Biology, v. 34, n. 1, p. 309-316, 2013.
dc.identifier1423-0380
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/8910
dc.identifier10.1007/s13277-012-0552-7
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8882198
dc.descriptionThe aim of this study was to investigate the density of mast cells and microvessels in minor salivary gland tumors. Forty-one cases of minor salivary gland tumors (pleomorphic adenoma, n = 10; adenoid cystic carcinoma, n = 11; mucoepidermoid carcinoma, n = 10; and polymorphous low-grade adenocarcinoma) were investigated using immunohistochemistry for mast cell tryptase and von-Willebrand factor. Density of mast cells was higher in mucoepidermoid carcinoma; however, no differences in the number of these cells were observed between the different types of tumors (p > 0.05). The number of mast cells was higher in periparenchymal areas in all tumors, but the difference was not significant (p > 0.05). Mucoepidermoid carcinoma showed the largest number of periparenchymal mast cells, whereas pleomorphic adenomas showed the smallest number of intraparenchymal mast cells (p > 0.05). The highest microvessel density was observed in mucoepidermoid carcinomas, being this difference statistically significant when mucoepidermoid carcinoma was compared to pleomorphic adenoma (p = 0.0034) and polymorphous low-grade adenocarcinoma (p = 0.004). Microvessel density was significantly higher in adenoid cystic carcinoma when compared to pleomorphic adenoma (p = 0.0406) and polymorphous low-grade adenocarcinoma (p = 0.0123). Comparison of mast cells and microvessel densities showed no significant difference between tumors. A quantitative difference in mast cells and microvessels was observed, particularly in mucoepidermoid carcinoma, a finding supporting the aggressive behavior of malignant salivary gland tumors without myoepithelial differentiation. Further studies are needed to determine the role of mast cells in angiogenesis, as well as in the development and biological behavior of these tumors.
dc.formatapplication/pdf
dc.languageeng
dc.publisherSpringer
dc.rightsopen access
dc.subjectSalivary gland tumors
dc.subjectMast cell
dc.subjectMicrovessels
dc.subjectMastócitos
dc.subjectMicrovasos/patologia
dc.subjectNeoplasias das Glândulas Salivares/irrigação sanguínea
dc.subjectNeoplasias das Glândulas Salivares/patologia
dc.subjectGlândulas Salivares Menores
dc.subjectAdenocarcinoma/irrigação sanguínea
dc.subjectAdenocarcinoma/patologia
dc.subjectAdenoma Pleomorfo/irrigação sanguínea
dc.subjectAdenoma Pleomorfo/patologia
dc.subjectCarcinoma Adenoide Cístico/irrigação sanguínea
dc.subjectCarcinoma Adenoide Cístico/patologia
dc.subjectCarcinoma Mucoepidermoide/irrigação sanguínea
dc.subjectHumanos
dc.subjectTriptases/análise
dc.subjectMarcadores Biológicos de Tumor
dc.subjectFator de von Willebrand/análise
dc.titleDensity of mast cells and microvessels in minor salivary gland tumors
dc.typeArticle


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