Monitoring of canine parvovirus (CPV) strains detected in vaccinated puppies in Brazil

dc.creatorCastro, T. X.
dc.creatorCosta, E. M.
dc.creatorLeite, J. P.
dc.creatorLabarthe, N. V.
dc.creatorGarcia, R. C. N. Cubel
dc.date2018-03-15T17:45:44Z
dc.date2018-03-15T17:45:44Z
dc.date2011
dc.date.accessioned2023-09-26T22:42:25Z
dc.date.available2023-09-26T22:42:25Z
dc.identifierCASTRO, T. X. et al. Monitoring of canine parvovirus (CPV) strains detected in vaccinated puppies in Brazil. Research in Veterinary Science, v.90, n.2, p.336-340, 2011.
dc.identifier0034-5288
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/25333
dc.identifier10.1016/j.rvsc.2010.06.005
dc.identifier1532-2661
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8882178
dc.descriptionThe objective of this study was to investigate, by partial sequencing of VP2 protein, the variability of CPV detected in 37 fecal samples collected from vaccinated puppies with enteritis. Laboratorial diagnosis of CPV was confirmed by HA/HI and PCR and, for sequencing analyses, two different regions of the VP2 gene were amplified by PCR. From 1995 to 2004, all strains were characterized as CPV-2a. After that, both CPV-2a and CPV-2b were detected. All CPV-2a showed a non-synonymous mutation in the residue 297 (Ser→Ala). A synonymous substitution at the AA 574 was also observed in 15/37 samples. Our findings indicate that the cases of vaccine failure are most likely not associated to the mutations detected in the sequenced regions. However, the monitoring of genotyping mutations that led to new CPV strains is essential to determinate if current vaccines will keep providing protection against all new future variants.
dc.description2030-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsrestricted access
dc.subjectParvovirus Canino
dc.subjectAnálise de Sequência
dc.subjectReação em Cadeia da Polimerase
dc.subjectVacina
dc.subjectEnterite
dc.subjectCanine parvovirus
dc.subjectEnteritis
dc.subjectVaccine
dc.subjectPCR
dc.subjectSequence analysis
dc.titleMonitoring of canine parvovirus (CPV) strains detected in vaccinated puppies in Brazil
dc.typeArticle


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