Prenatal exposure to misoprostol and vascular disruption defects: a case-control study

dc.creatorVargas, F. R.
dc.creatorSchuler-Faccini, L.
dc.creatorBrunoni, D.
dc.creatorKim, C.
dc.creatorMeloni, V. F. A.
dc.creatorSugayama, S. M. M.
dc.creatorAlbano, L.
dc.creatorLlerena Junior, Juan Clinton
dc.creatorAlmeida, J. C. C.
dc.creatorDuarte, A.
dc.creatorCavalcanti, D. P.
dc.creatorGoloni-Bertollo, E.
dc.creatorConte, A.
dc.creatorKoren, G.
dc.creatorAddis, A.
dc.date2010-08-23T16:00:16Z
dc.date2010-08-23T16:00:16Z
dc.date2000
dc.date.accessioned2023-09-26T22:42:23Z
dc.date.available2023-09-26T22:42:23Z
dc.identifierVARGAS, F. R. et al. Prenatal exposure to misoprostol and vascular disruption defects: a case-control study. Am. J. Med. Genet., New York, v. 95, n. 4, p. 302-306, dec. 2000.
dc.identifier0148-7299
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/210
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8882170
dc.descriptionPrenatal exposure to misoprostol has beenassociated with Moebius and limb defects.Vascular disruption has been proposed asthe mechanism for these teratogenic effects. The present study is a multicenter, casecontrol study that was designed to compare the frequency of prenatal misoprostol use between mothers of Brazilian children diagnosedwith vascular disruption defects andmatched control mothers of children diagnosed with other types of defects. A total of 93 cases and 279 controls were recruited in eight participating centers. Prenatal exposure was identified in 32 infants diagnosed with vascular disruption defects (34.4 percent) compared with only 12 (4.3 percent) in the control group (P menor que 0.0000001). Our data suggest thatprenatal exposure to misoprostol is associated to the occurrence of vascular disruption defects in the newborns.
dc.formatapplication/pdf
dc.languageeng
dc.rightsopen access
dc.subjectVascular Disruption
dc.subjectMoebius sequence
dc.subjectLimb Defect
dc.subjectMisoprostol
dc.subjectAnormalidades Induzidas por Medicamentos - fisiopatologia
dc.subjectAbortivos não Esteróides - efeitos adversos
dc.subjectFeto - irrigação sanguínea
dc.subjectMisoprostol - efeitos adversos
dc.subjectEfeitos Tardios da Exposição Pré-Natal
dc.subjectGravidez
dc.titlePrenatal exposure to misoprostol and vascular disruption defects: a case-control study
dc.typeArticle


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