Different patterns of disease in two inbred mouse strains infected with a clone of Leishmania mexicana amazonensis

dc.creatorBarral Netto, Manoel
dc.creatorCardoso, Silvia Andrade
dc.creatorBarral, Aldina Maria Prado
dc.date2018-05-09T18:11:44Z
dc.date2018-05-09T18:11:44Z
dc.date1987
dc.date.accessioned2023-09-26T22:42:08Z
dc.date.available2023-09-26T22:42:08Z
dc.identifierBARRAL NETTO, M.; CARDOSO, A. A.; BARRAL, A. M. P. Different patterns of disease in two inbred mouse strains infected with a clone of Leishmania mexicana amazonensis. Acta Tropica, v. 44, p. 5-11, 1987.
dc.identifier0001-706X
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/26346
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8882131
dc.descriptionGrant AI-16282 (National Institutes of Health - USA) and from the Conselho Nacional de Desenvolvimento Cientifico e Tecnològico (CNPq-Brasil).
dc.descriptionWe have infected BALB/c and C57BL/6 mice with a cloned Leishmania mexicana amazonensis population, obtained from the "Maria" strain. Progres¬ sion of infection and histopathological examination confirmed the extreme susceptibility of BALB/c mice and the resistant pattern ofthe C57 BL/6. Anti- Leishmania antibody titers were higher in BALB/c than in C57BL/6 mice through the period of infection. Tests of delayed type hypersensitivity reaction with Leishmania antigens were positive in both strains in the beginning ofthe infection, but were negative later on in BALB/c mice. Our results are similar to those obtained with mixed parasite populations, and rule out the possibility of selection among different parasite subpopulations as responsible for the diver¬ gent course of the disease exhibited by these two strains of mice.
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsopen access
dc.subjectLeishmaniose cutânea
dc.subjectLeishmaniose murina
dc.subjectLeishmania
dc.subjectParasite clones
dc.subjectL. mexicana
dc.subjectCutaneous leishmaniasis
dc.subjectMurine leishmaniasis
dc.subjectLeishmania
dc.subjectClones de parasitas
dc.subjectL. mexicana
dc.titleDifferent patterns of disease in two inbred mouse strains infected with a clone of Leishmania mexicana amazonensis
dc.typeArticle


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