Myocardial changes in acute Trypanosoma cruzi infection. Ultrastructural evidence of immune damage and the role of microangiopathy

dc.creatorAndrade, Zilton de Araújo
dc.creatorAndrade, Sonia Gumes
dc.creatorCorrea, Rosaly
dc.creatorSadigursky, Moysés
dc.creatorFerrans, Victor J.
dc.date2012-10-19T21:29:50Z
dc.date2012-10-19T21:29:50Z
dc.date1994
dc.date.accessioned2023-09-26T22:40:51Z
dc.date.available2023-09-26T22:40:51Z
dc.identifierANDRADE, Z.A. et al. Myocardial changes in acute Trypanosoma cruzi infection. Ultrastructural evidence of immune damage and the role of microangiopathy. American Journal of Pathology, v. 144, n. 6, p. 1403-11, jun. 1994.
dc.identifier0002-9440
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/5701
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8881857
dc.descriptionHistological and ultrastructural studies of the hearts of dogs sacrificed 18 to 26 days after intraperitoneal inoculation with 4 x 10(5) blood forms of the 12 SF strain of Trypanosoma cruzi/kg of body weight disclosed myocarditis characterized by parasitic invasion of some myocytes, damage and necrosis of nonparasitized myocytes, and interstitial infiltration by mononuclear cells. Nonparasitized myocytes showed alterations ranging from mild edema to severe myocytolysis. These changes often were accompanied by contacts of myocytes with lymphocytes (both granular and agranular) and macrophages. These contacts were characterized by focal loss of the myocyte basement membrane and close approximation of the plasma membranes of the two cells. Contacts between lymphocytes and capillary endothelial cells were also frequent. Platelet aggregates and fibrin microthrombi were observed in some capillaries. Our findings suggest that immune effector cells play a major role in the pathogenesis of the myocyte damage and the microangiopathy in acute Chagas' disease.
dc.formatapplication/pdf
dc.languageeng
dc.rightsopen access
dc.subjectCardiomiopatia Chagásica/patologia
dc.subjectVasos Coronários/patologia
dc.subjectCoração/parasitologia
dc.subjectMiocárdio/patologia
dc.subjectMiocárdio/ultraestrutura
dc.subjectTrypanosoma cruzi/ultraestrutura
dc.subjectAnimais
dc.subjectComunicação Celular
dc.subjectCardiomiopatia Chagásica/imunologia
dc.subjectCães
dc.subjectEndotélio Vascular/patologia
dc.subjectEndotélio Vascular/ultraestrutura
dc.subjectLinfócitos/patologia
dc.subjectLinfócitos/ultraestrutura
dc.subjectMacrófagos/patologia
dc.subjectMacrófagos/ultraestrutura
dc.subjectMicrocirculação
dc.subjectMicroscopia Eletrônica
dc.subjectNecrose
dc.titleMyocardial changes in acute Trypanosoma cruzi infection. Ultrastructural evidence of immune damage and the role of microangiopathy
dc.typeArticle


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