Origins, Admixture Dynamics, and Homogenization of the African Gene Pool in the Americas

dc.creatorGouveia, Mateus H
dc.creatorBorda, Victor
dc.creatorLeal, Thiago P
dc.creatorMoreira, Rennan G
dc.creatorBergen, Andrew W
dc.creatorKehdy, Fernanda S G
dc.creatorAlvim, Isabela
dc.creatorAquino, Marla M
dc.creatorAraujo, Gilderlanio S
dc.creatorAraujo, Nathalia M
dc.creatorFurlan, Vinicius
dc.creatorLiboredo, Raquel
dc.creatorMachado, Moara
dc.creatorMagalhaes, Wagner C S
dc.creatorMichelin, Lucas A
dc.creatorRodrigues, Maíra R
dc.creatorSoares, Fernanda Rodrigues
dc.creatorSant Anna, Hanaisa P
dc.creatorSantolalla, Meddly L
dc.creatorScliar, Marília O
dc.creatorSouza, Giordano Soares
dc.creatorZamudio, Roxana
dc.creatorZolini, Camila
dc.creatorBortolini, Maria Catira
dc.creatorDean, Michael
dc.creatorGilman, Robert H
dc.creatorGuio, Heinner
dc.creatorRocha, Jorge
dc.creatorPereira, Alexandre C
dc.creatorBarreto, Mauricio Lima
dc.creatorHorta, Bernardo L
dc.creatorCosta, Maria F. Lima
dc.creatorMbulaiteye, Sam M
dc.creatorChanock, Stephen J
dc.creatorTishkoff, Sarah A
dc.creatorYeager, Meredith
dc.creatorSantos, Eduardo Tarazona
dc.date2020-08-13T12:48:59Z
dc.date2020-08-13T12:48:59Z
dc.date2020
dc.date.accessioned2023-09-26T22:40:33Z
dc.date.available2023-09-26T22:40:33Z
dc.identifierGOUVEIA, Mateus H. et al. Origins, Admixture Dynamics, and Homogenization of the African Gene Pool in the Americas. Molecular Biology and Evolution, v. 37, n. 6, p. 1647–1656, 2020.
dc.identifier0737-4038
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/42743
dc.identifier10.1093/molbev/msaa033
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8881792
dc.descriptionBARRETO, Mauricio Lima. Fundação Oswaldo Cruz. Centro de Integração de Dados e Conhecimento para Saúde. 1Departamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil 2Instituto de Pesquisa Rene Rachou, Fundação Oswaldo Cruz, Belo Horizonte, MG, Brazil 3Center for Research on Genomics and Global Health, National Human Genome Research Institute, Bethesda, MD 4Departamento de Estatística, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil 5Laboratorio de Genomica, Centro de Laboratórios Multiusuário (CELAM), ICB, UFMG, Belo Horizonte, MG, Brazil 6Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD 7Laboratório de Hansenıase, Instituto Oswaldo Cruz, Fundaçao Oswaldo Cruz, Rio de Janeiro, RJ, Brazil 8Laboratório de Genética Humana e Médica, Instituto de Ciencias Biologicas, Universidade Federal do Para – Campus Guama, Belem, PA, Brazil 9Instituto de Ciências Exatas e Tecnológicas, Universidade Federal de Viçosa, Campus UFV-Florestal, Florestal, MG, Brazil 10Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 11N ucleo de Ensino e Pesquisas do Instituto M ario Penna – NEP-IMP, Bairro Luxemburgo, Belo Horizonte, MG, Brazil 12Department of Genetics and Evolutionary Biology, Biosciences Institute, University of São Paulo, São Paulo, SP, Brazil 13Departamento de Patologia, Genética e Evolução, Instituto de Ciências Biológicas e Naturais, Universidade Federal do Triângulo Mineiro, Uberaba, MG, Brazil 14Melbourne Integrative Genomics, The University of Melbourne, Melbourne, VIC, Australia 15Human Genome and Stem Cell Research Center, Biosciences Institute, University of S~ao Paulo, S~ao Paulo, SP, Brazil 16Beagle, Belo Horizonte, MG, Brazil 17Mosaico Translational Genomics Initiative, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil 18Departamento de Genética, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil 19Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD 20Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21Universidad Peruana Cayetano Heredia, Lima, Peru 22Instituto Nacional de Salud, Lima, Peru 23Departamento de Biologia, Faculdade de Ci^encias, Universidade do Porto, Porto, Portugal 24CIBIO/InBIO: Research Center in Biodiversity and Genetic Resources, Vairao, Portugal 25Instituto do Coração, Universidade de São Paulo, São Paulo, SP, Brazil 26Instituto de Saúde Coletiva, Universidade Federal da Bahia, Salvador, BA, Brazil 27Center of Data and Knowledge Integration for Health (CIDACS), Fundac¸~ao Oswaldo Cruz (FIOCRUZ), Salvador, Brazil 28Programa de Pós-Graduação em Epidemiologia, Universidade Federal de Pelotas, Pelotas, RS, Brazil 29Department of Genetics and Department of Biology, University of Pennsylvania, Philadelphia, PA 30Instituto de Estudos Avanc¸ados Transdisciplinares, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil
dc.descriptionBrazilian Ministry of Health (Department of Science and Technology from the Secretaria de Ci^encia, Tecnolog ıa e Insumos Estrat egicos) through Financiadora de Estudos e Projetos (FINEP) to the EPIGEN-Brazil Initiative. The EPIGENBrazil investigators were also supported by the Coordenac¸~ao de Aperfeic¸oamento de Pessoal de N ıvel Superior of the Brazilian Ministry of Education (CAPES Agency). E.T.S., M.H.G., V.B., T.P.L., and M.F.L.C. were supported by Brazilian National Research Council (CNPq), Fundac¸~ao de Amparo a Pesquisa de Minas Gerais (FAPEMIG), and Pr o-Reitoria de Pesquisa da Universidade Federal de Minas Gerais. M.H.G. performed part of this study as CAPES-PDSE fellow, V.B. was a CAPES-PEC-PG fellow. M.L.S. was a TWAS-CNPq PhD fellow. MHG is supported by the Intramural Research Program of the National Institutes of Health in the Center for Research on Genomics and Global Health (CRGGH). The CRGGH is supported by the National Human Genome Research Institute, the National Institute of Diabetes and Digestive and Kidney Diseases, the Center for Information Technology, and the Office of the Director at the National Institutes of Health (1ZIAHG200362). Tishkoff Laboratory is funded by the National Institutes of Health (1R01DK104339-0 and 1R01GM113657-01). EMBLEM is funded by the Intramural Research Program of the Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI) (HHSN261201100063C and HHSN261201100007I) and, in part, by the Intramural Research Program, National Institute of Allergy, and Infectious Diseases (SJR), National Institutes of Health, Department of Health and Human Services. Bioinformatics support was provided by the Sagarana HPC cluster, CPADICB- UFMG, Brazil.
dc.descriptionThe Transatlantic Slave Trade transported more than 9 million Africans to the Americas between the early 16th and the mid-19th centuries. We performed a genome-wide analysis using 6,267 individuals from 25 populations to infer how different African groups contributed to North-, South-American, and Caribbean populations, in the context of geographic and geopolitical factors, and compared genetic data with demographic history records of the Transatlantic Slave Trade. We observed that West-Central Africa and Western Africa-associated ancestry clusters are more prevalent in northern latitudes of the Americas, whereas the South/East Africa-associated ancestry cluster is more prevalent in southern latitudes of the Americas. This pattern results from geographic and geopolitical factors leading to population differentiation. However, there is a substantial decrease in the between-population differentiation of the African gene pool within the Americas, when compared with the regions of origin from Africa, underscoring the importance of historical factors favoring admixture between individuals with different African origins in the New World. This between-population homogenization in the Americas is consistent with the excess of West-Central Africa ancestry (the most prevalent in the Americas) in the United States and Southeast-Brazil, with respect to historical-demography expectations. We also inferred that in most of the Americas, intercontinental admixture intensification occurred between 1750 and 1850, which correlates strongly with the peak of arrivals from Africa. This study contributes with a population genetics perspective to the ongoing social, cultural, and political debate regarding ancestry, admixture, and the mestizaje process in the Americas.
dc.formatapplication/pdf
dc.languageeng
dc.publisherOxford University Press
dc.rightsopen access
dc.subjectDiáspora
dc.subjectExploração de escravos
dc.subjectDinâmica de populações
dc.subjectPopulações de ascendencia africana
dc.subjectAfrican diaspora
dc.subjectTransatlantic Slave Trade
dc.subjectAdmixture dynamics
dc.subjectMestizaje
dc.titleOrigins, Admixture Dynamics, and Homogenization of the African Gene Pool in the Americas
dc.typeArticle


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