Prevalence of the CCR5Delta32 mutation in Brazilian populations and cell susceptibility to HIV-1 infection.

dc.creatorGrimaldi, Rogério
dc.creatorShindo, Nice
dc.creatorAcosta, Angelina Xavier
dc.creatorDourado, Inês
dc.creatorBrites, Carlos
dc.creatorCarvalho, Ozenilda de Melo
dc.creatorBrito, Ivo
dc.creatorBou-Habib, Dumith Chequer
dc.creatorCastro Filho, Bernardo Galvão
dc.date2014-08-06T13:49:33Z
dc.date2014-08-06T13:49:33Z
dc.date2002
dc.date.accessioned2023-09-26T22:40:27Z
dc.date.available2023-09-26T22:40:27Z
dc.identifierGRIMALDI, R. et al. Prevalence of the CCR5Delta32 mutation in Brazilian populations and cell susceptibility to HIV-1 infection. Human Genetics, v. 111, n. 1, p. 102-104, 2002.
dc.identifier0340-6717
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/8137
dc.identifier10.1007/s00439-002-0747-x
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8881769
dc.descriptionWe investigated the occurrence of the CCR5Delta32 mutation in various regional ethnic groups in Brazil and tested the resistance of mutant peripheral blood mononuclear cells (PBMCs) to infection by HIV-1 in vitro. The heterozygous prevalence was 5.3% in uninfected African descendents and 8.8% in HIV-1-positive individuals (neither population had Delta32/Delta32). German descendents were 11% heterozygous and l% Delta32/Delta32. Amerindians were exclusively CCR5/CCR5. Heterozygous uninfected PBMCs showed partial resistance to R5-HIV-1 strains in vitro, but no resistance to X4 virus. HIV-1-positive CCR5/CCR5 had higher viral loads than did heterozygous cells.
dc.formatapplication/pdf
dc.languageeng
dc.publisherSpringer Verlag
dc.rightsrestricted access
dc.subjectInfecções por HIV/epidemiologia
dc.subjectInfecções por HIV/genética
dc.subjectHIV-1/crescimento & desenvolvimento
dc.subjectMutação
dc.subjectReceptores CCR5/genética
dc.subjectAlelos
dc.subjectBrasil/epidemiologia
dc.subjectCélulas Cultivadas
dc.subjectProgressão da Doença
dc.subjectTransmissão de Doença Infecciosa
dc.subjectDeleção de Genes
dc.subjectPredisposição Genética para Doença
dc.subjectLeucócitos Mononucleares/virologia
dc.subjectHumanos
dc.subjectPrevalência
dc.titlePrevalence of the CCR5Delta32 mutation in Brazilian populations and cell susceptibility to HIV-1 infection.
dc.typeArticle


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