Akkermansia muciniphila mediates negative effects of IFN gamma on glucose metabolism.

dc.creatorGreer, Renee L.
dc.creatorDong, Xiaoxi
dc.creatorMoraes, Ana Carolina F.
dc.creatorZielke, Ryszard A.
dc.creatorRernandes, Gabriel R
dc.creatorPeremyslova, Ekaterina
dc.creatorVasquez-Perez, Stephany
dc.creatorSchoenborn, Alexi A.
dc.creatorGomes, Everton P.
dc.creatorPereira, Alexandre C.
dc.creatorFerreira, Sandra R. G.
dc.creatorYao, Michael
dc.creatorFuss, Ivan J.
dc.creatorStrober, Warren
dc.creatorSikora, Aleksandra E.
dc.creatorTaylor, Gregory A.
dc.creatorGulati, Ajay S.
dc.creatorMorgun, Andrey
dc.creatorShulzhenko, Natalia
dc.date2017-04-10T19:29:03Z
dc.date2017-04-10T19:29:03Z
dc.date2016
dc.date.accessioned2023-09-26T22:40:21Z
dc.date.available2023-09-26T22:40:21Z
dc.identifierGREER, Renee L. et al. Akkermansia muciniphila mediates negative effects of IFN gamma on glucose metabolism. NATURE COMMUNICATIONS, v.7, article ID 13329, 13p, 2016
dc.identifier2041-1723
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/18353
dc.identifier10.1038/ncomms13329
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8881750
dc.descriptionCross-talk between the gut microbiota and the host immune system regulates host metabolism, and its dysregulation can cause metabolic disease. Here, we show that the gut microbe Akkermansia muciniphila can mediate negative effects of IFN gamma on glucose tolerance. In IFN gamma-deficient mice, A. muciniphila is significantly increased and restoration of IFN gamma levels reduces A. muciniphila abundance. We further show that IFN gamma-knockout mice whose microbiota does not contain A. muciniphila do not show improvement in glucose tolerance and adding back A. muciniphila promoted enhanced glucose tolerance. We go on to identify Irgm1 as an IFN gamma-regulated gene in the mouse ileum that controls gut A. muciniphila levels. A. muciniphila is also linked to IFN gamma-regulated gene expression in the intestine and glucose parameters in humans, suggesting that this trialogue between IFN gamma, A. muciniphila and glucose tolerance might be an evolutionally conserved mechanism regulating metabolic health in mice and humans
dc.formatapplication/pdf
dc.languageeng
dc.publisherNature
dc.rightsopen access
dc.subjectimunologia muconasal
dc.subjectMucosal immunology
dc.subjectmetabolism
dc.subjectmicrobiota
dc.subjectinterferons
dc.titleAkkermansia muciniphila mediates negative effects of IFN gamma on glucose metabolism.
dc.typeArticle


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