Brazilian HTLV type 2a strains from intravenous drug users (IDUs) appear to have originated from two sources: Brazilian Amerindians and European/North American IDUs.

dc.creatorAlcantara, Luiz Carlos Júnior
dc.creatorShindo, Nice
dc.creatorVan Dooren, Sonia
dc.creatorSalemi, Marco
dc.creatorCosta, Maria Cristina Ramos
dc.creatorKashima, Simone G
dc.creatorCovas, Dimas Tadeu
dc.creatorVandamme, Anne-Mieke
dc.date2012-05-04T19:42:09Z
dc.date2012-05-04T19:42:09Z
dc.date2003
dc.date.accessioned2023-09-26T22:39:59Z
dc.date.available2023-09-26T22:39:59Z
dc.identifierALCANTARA, L.C. et al. Brazilian HTLV type 2a strains from intravenous drug users (IDUs) appear to have originated from two sources: Brazilian Amerindians and European/North American IDUs. AIDS Research and Human Retroviruses, v. 19, n. 6, p. 519-523, jun. 2003.
dc.identifier0889-2229
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/3883
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8881683
dc.descriptionIn Brazil, HTLV-2 has been detected in blood donors, in intravenous drug users (IDUs) from urban areas, and in Amerindians living in the Amazon basin. Of the three main HTLV-2 subtypes (2a, 2b, and 2d) only subtype 2a has been detected in Brazil. However, a molecular variant of subtype 2a (also called HTLV-2c) characterized by an extended Tax protein has been isolated from Brazilian blood donors, IDUs, and Indians. Here, we analyzed HTLV-2 isolates from 10 IDUs and a Chilean woman living in Salvador, Bahia, Brazil. Sequencing of env, pX, and long terminal repeat (LTR) genes demonstrated that 10 of the isolates are related to the Brazilian subtype 2a molecular variant described previously. We show that most HTLV-2a Brazilian strains comprise a phylogenetic group harboring a considerable degree of diversity within the env region but not within the LTR region. Interestingly, we demonstrated for the first time in Brazil the presence of a subtype 2a in IDUs that is closely related to the prototype Mo but distinct from the Brazilian 2a molecular variant.
dc.formatapplication/pdf
dc.languageeng
dc.rightsopen access
dc.subjectInfecções por HTLV-II/epidemiologia
dc.subjectVírus 2 Linfotrópico T Humano/classificação
dc.subjectÍndios Sul-Americanos
dc.subjectAbuso de Substâncias por Via
dc.subjectIntravenosa/complicações
dc.subjectEuropa (Continente)/epidemiologia
dc.subjectProdutos do Gene env/química
dc.subjectDados de Sequência Molecular
dc.subjectFilogenia
dc.subjectProteínas Oncogênicas de Retroviridae/química
dc.subjectAnálise de Sequência de DNA
dc.subjectSequências Repetidas Terminais/genética
dc.titleBrazilian HTLV type 2a strains from intravenous drug users (IDUs) appear to have originated from two sources: Brazilian Amerindians and European/North American IDUs.
dc.typeArticle


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