Significance and fate of septal fibrosis of the liver

dc.creatorSouza, Márcia Maria de
dc.creatorTolentino, Miguel
dc.creatorAssis, Bárbara Cristina Alves de
dc.creatorde Oliveira Gonzalez, Ana Cristina
dc.creatorSilva, Tânia Maria Correia
dc.creatorAndrade, Zilton de Araújo
dc.date2016-08-08T13:27:25Z
dc.date2016-08-08T13:27:25Z
dc.date2006
dc.date.accessioned2023-09-26T22:39:55Z
dc.date.available2023-09-26T22:39:55Z
dc.identifierSOUZA, M. M. et al. Significance and fate of septal fibrosis of the liver. Hepatology Research, v. 35, p. 31–36, 2006.
dc.identifier1386-6346
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/15201
dc.identifier10.1016/j.hepres.2006.01.010
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8881668
dc.descriptionSeptal fibrosis commonly occurs during chronic diseases of the liver. It is experimentally reproduced in a proportion of rats treated with pig-serum, and in 100% of rats infected with Capillaria hepatica. These models have only been used in relatively short-term studies. To contribute to the natural history and significance of hepatic septal fibrosis it is important to disclose its fate after prolonged observation, and following partial or total withdrawal of its inciting cause. Adult Wistar rats were sacrificed 3, 6, 9 and 12 months following inoculation of 800 embryonated eggs of C. hepatica. Besides routine histology, liver sections were submitted to immunohistochemical, immunofluorescence and ultrastructural techniques for the identification of cells and extracellular matrix components present in the fibrous septa. Septal blood vessels were studied after portal vein perfusion with India-ink, while the hepatic functional profile and levels of anti-C. hepatica antibodies were determined in collected sera. Results revealed that all parasites were already dead 2 months from inoculation, and the accumulated eggs in the liver lost their capacity to embryonate around the 4th-6th month, when progressive reduction in the number of cells and in the amount of collagen occurred in the septa. Septal fibrosis persisted throughout the time of experimentation (12 months). This fibrosis was seen as a supporting stroma for septal vessels that conducted portal blood directly to the sinusoids. Thus, persistence of fibrosis was probably related to its morphological and functional association with blood vessels.
dc.formatapplication/pdf
dc.languageeng
dc.publisherWiley
dc.rightsopen access
dc.subjectCapillaria hepatica
dc.subjectSeptal hepatic fibrosis
dc.subjectFibrosis reversibility
dc.titleSignificance and fate of septal fibrosis of the liver
dc.typeArticle


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