Trypanosoma cruzi Modulates the Expression of Rabs and Alters the Endocytosis in Mouse Cardiomyocytes In Vitro

dc.creatorBatista, Denise G. J.
dc.creatorSilva, Cristiane F.
dc.creatorMota, Renata A.
dc.creatorCosta, Lilian C.
dc.creatorMeirelles, Maria N. L.
dc.creatorMeuser-Batista, Marcelo
dc.creatorSoeiro, Maria N. C.
dc.date2020-01-30T17:34:12Z
dc.date2020-01-30T17:34:12Z
dc.date2006
dc.date.accessioned2023-09-26T22:39:11Z
dc.date.available2023-09-26T22:39:11Z
dc.identifierBATISTA, Denise G. J. et al. Trypanosoma cruzi Modulates the Expression of Rabs and Alters the Endocytosis in Mouse Cardiomyocytes In Vitro. Journal of Histochemistry & Cytochemistry, v. 54, n. 6, p. 604-614, 2006.
dc.identifier0022-1554
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/39647
dc.identifier10.1369/jhc.5A6654.2005
dc.identifier1551-5044
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8881517
dc.descriptionChagas disease is an incurable illness caused by the protozoan Trypanosoma cruzi. Cardiomyocytes represent important targets for the parasite infection and alterations in their physiology were reported. Because endocytosis is involved in different cellular events and guanosine triphosphatase (GTPase) Rab proteins play important roles in various aspects of the membrane traffic, our aim was to characterize the expression of Rab proteins in T. cruzi–infected cardiomyocytes, which displayed a downregulation of Rab7 and Rab11, whereas the expression of Rab5a was maintained in the infected cultures even after longer periods of parasite internalization, but early endosome antigen 1 was partially downregulated. The parasite infection also decreased the uptake of fluid phase ligands by the cardiac cultures. The regulation of GTPase proteins and effector molecules can contribute to the altered physiology of the host cells by modifying the normal incoming of nutrients as well as interfering with other important events related to the endocytic pathway.
dc.description2025-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherSAGE Publications
dc.rightsrestricted access
dc.subjectTrypanosoma cruzi
dc.subjectCardiomiócitos
dc.subjectEndocitose
dc.subjectTrifosfatase de guanosina
dc.subjectCardiomyocytes
dc.subjectTrypanosoma cruzi
dc.subjectEndocytosis
dc.subjectGTPases
dc.subjectRab proteins
dc.titleTrypanosoma cruzi Modulates the Expression of Rabs and Alters the Endocytosis in Mouse Cardiomyocytes In Vitro
dc.typeArticle


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