Comparative study of the expression of cellular cycle proteins in cervical intraepithelial lesions

dc.creatorQueiroz, Conceição
dc.creatorSilva, Tânia Maria Correia
dc.creatorAlves, Venâncio Avancini Ferreira
dc.creatorVilla, Luisa L.
dc.creatorCosta, Maria Cecília
dc.creatorTravassos, Ana Gabriela Álvares
dc.creatorAraújo Filho, José Bouzas
dc.creatorStudart, Eduardo
dc.creatorCheto, Tatiana
dc.creatorFreitas, Luiz Antonio Rodrigues de
dc.date2014-07-04T13:32:49Z
dc.date2014-07-04T13:32:49Z
dc.date2006
dc.date.accessioned2023-09-26T22:39:05Z
dc.date.available2023-09-26T22:39:05Z
dc.identifierQUEIROZ, C. et al. P16(INK4a) expression as a potential prognostic marker in cervical pre-neoplastic and neoplastic lesions. Pathology Research Practice, v. 202, n. 2, p. 731-737, 2006.
dc.identifier0344-0338
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/7867
dc.identifier10.1016/j.prp.2006.07.003
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8881493
dc.descriptionInteraction of human papilloma virus oncoproteins E6 and E7 with cell cycle proteins leads to disturbances of the cell cycle mechanism and subsequent alteration in the expression of some proteins, such as p16INK4a, cyclin D1, p53 and KI67. In this study, we compared alterations in the expression of these proteins during several stages of intraepitelial cervical carcinogenesis. Accordingly, an immunohistochemical study was performed on 50 cervical biopsies, including negative cases and intraepithelial neoplasias. The expression patterns of these markers were correlated with the histopathological diagnosis and infection with HPV. The p16INK4a, followed by Ki67, showed better correlation with cancer progression than p53 and cyclin D1, which recommends their use in the evaluation of cervical carcinogenesis. These monoclonal antibodies can be applied to cervical biopsy specimens to identify lesions transformed by oncogenic HPV, separating CIN 1 (p16INK4a positive) and identifying high-grade lesions by an increase in the cellular proliferation index (Ki67). In this way, we propose immunomarkers that can be applied in clinical practice to separate patients who need a conservative therapeutic approach from those who require a more aggressive treatment.
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsopen access
dc.subjectCervical neoplasia
dc.subjectP16INK4a
dc.subjectCyclin D1
dc.subjectKi67
dc.subjectp53
dc.subjectProteínas de Ciclo Celular/metabolismo
dc.subjectNeoplasia Intraepitelial Cervical/metabolismo
dc.subjectNeoplasias do Colo do Útero/metabolismo
dc.subjectAdulto
dc.subjectIdoso
dc.subjectIdoso de 80 Anos ou mais
dc.subjectBiópsia
dc.subjectProliferação de Células
dc.subjectNeoplasia Intraepitelial Cervical/patologia
dc.subjectColo do Útero/anatomia & histologia
dc.subjectColo do Útero/metabolismo
dc.subjectCiclina D1/metabolismo
dc.subjectInibidor p16 de Quinase Ciclina-Dependente/metabolismo
dc.subjectFeminino
dc.subjectHumanos
dc.subjectAntígeno Ki-67/metabolismo
dc.subjectMeia-Idade
dc.subjectMarcadores Biológicos de Tumor/metabolismo
dc.subjectNeoplasias do Colo do Útero/patologia
dc.titleComparative study of the expression of cellular cycle proteins in cervical intraepithelial lesions
dc.typeArticle


Este ítem pertenece a la siguiente institución