TRPing on the pore phenomenon: what do we know about transient receptor potential ion channel-related pore dilation up to now?

dc.creatorFerreira, L. G. B.
dc.creatorFaria, R. X.
dc.date2017-03-23T16:47:25Z
dc.date2017-03-23T16:47:25Z
dc.date2016
dc.date.accessioned2023-09-26T22:37:58Z
dc.date.available2023-09-26T22:37:58Z
dc.identifierFERREIRA, L. G. B.; FARIA, R. X. TRPing on the pore phenomenon: what do we know about transient receptor potential ion channel-related pore dilation up to now?. J Bioenerg Biomembr, v.48, n.1, p.1–12, Feb. 2016.
dc.identifier0145-479
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/18143
dc.identifier10.1007/s10863-015-9634-8
dc.identifier1573-6881
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8881260
dc.descriptionIon channels allow for rapid ion diffusion through the plasma membrane. In some conditions, ion channels induce changes in the critical plasma membrane permeability that permit 900-Da solutes to enter cells. This process is known as the pore phenomenon. Some transient receptor potential (TRP) channel subtypes have been highlighted such as the P2X7 receptor, plasma membrane VDAC-1 channel, and pannexin hemichannels. The TRP ion channels are considered multimodal transducers that respond to several kinds of stimuli. In addition, many TRP channel subtypes are involved in physiological and pathophysiological processes such as inflammation, pain, and cancer. The TRPA1, TRPM8, and TRPV1-4 subtypes have been shown to promote large-molecular-weight solute uptake, including impermeable fluorescent dyes, QX-314 hydrophilic lidocaine derivative, gabapentin, and antineoplastic drugs. This review discusses the current knowledge of TRP-associated pores and encourages scientists to study their features and explore them as novel therapeutic tools.
dc.description2030-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherSpringer Verlag (Germany)
dc.rightsrestricted access
dc.subjectDilatação do poro
dc.subjectCaptação de corante
dc.subjectCanais iônicos potenciais do receptor transitório
dc.subjectPore dilation
dc.subjectTransient receptor potential ion channels
dc.subjectTRPA1
dc.subjectTRPM8
dc.subjectTRPV1
dc.subjectTRPV2
dc.subjectTRPV3
dc.subjectTRPV4 .
dc.subjectDye uptake
dc.titleTRPing on the pore phenomenon: what do we know about transient receptor potential ion channel-related pore dilation up to now?
dc.typeArticle


Este ítem pertenece a la siguiente institución