Associations among immunological, parasitological and clinical parameters in canine visceral leishmaniasis: Emaciation, spleen parasitism, specific antibodies and leishmanin skin test reaction.

dc.creatordosSantos, Washington Luis Conrado
dc.creatorJesus, E. E
dc.creatorSilva, Moacir Paranhos
dc.creatorPereira, Andréa Mendes
dc.creatorSantos, Juliana C.
dc.creatorBaleeiro, Carolina de Oliveira
dc.creatorNascimento, Eliane Góes
dc.creatorMoreira Júnior, Edson Duarte
dc.creatorOliveira, Geraldo Gileno de Sá
dc.creatorPontes-de-Carvalho, Lain Carlos
dc.date2014-05-23T19:03:53Z
dc.date2014-05-23T19:03:53Z
dc.date2008
dc.date.accessioned2023-09-26T22:36:19Z
dc.date.available2023-09-26T22:36:19Z
dc.identifierSANTOS, Washington Luis Conrado dos et al. Associations among immunological, parasitological and clinical parameters in canine visceral leishmaniasis: Emaciation, spleen parasitism, specific antibodies and leishmanin skin test reaction. Veterinary Immunology and Immunopathology, v. 123, p. 251–259, 2008.
dc.identifier0165-2427
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/7650
dc.identifier10.1016/j.vetimm.2008.02.004
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8880908
dc.descriptionAssociations among parameters commonly used as markers of infection by Leishmania sp., or of susceptibility to visceral leishmaniasis, were investigated in 325 stray dogs from an area where this disease is endemic. Evidence of infection (presence of Leishmania in splenic cultures, positive leishmanin skin test (LST) or detection of anti-Leishmania antibody activity in the serum) was found in 57% of the animals. Both evidence of weight loss (x2-test, P = 0.0005) and presence of specific antibody activity in the serum (x2-test, P < 0.0001) were directly associated with positive splenic culture. The frequencies of animals with positive splenic culture were directly correlated with the intensities of antibody activity in the serum as measured by ELISA (relative risk of 3.4 for animals with moderate antibody levels and relative risk of 8.43 for animals with high-antibody levels). A negative association was observed between positive leishmanin skin test results and emaciation (x2, P = 0.0089). Furthermore, animals with positive splenic cultures and negative leishmanin skin test results had higher levels of total serum IgG (Kruskal–Wallis test, P = 0.001) and IgG2 (Kruskal–Wallis test, P = 0.05) than animals with negative splenic cultures, and were more emaciated than animals with negative LST results and positive splenic cultures. The data presented herein suggest that associating these common parameters may improve their performance in predicting susceptibility to canine visceral leishmaniasis.
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier Science B.V
dc.rightsopen access
dc.subjectLeishmanin skin test
dc.subjectCanine visceral leishmaniasis
dc.subjectLeishmania chagasi
dc.subjectLeishmania infantum; Spleen; Immunoglobulin isotypes
dc.subjectAnticorpos Antiprotozoários/imunologia
dc.subjectDoenças do Cão/imunologia
dc.subjectLeishmania/imunologia
dc.subjectLeishmaniose Visceral/veterinária
dc.subjectBaço/parasitologia
dc.subjectAnimais
dc.subjectAnticorpos Antiprotozoários/sangue
dc.subjectEspecificidade de Anticorpos
dc.subjectAntígenos de Protozoários/uso diagnóstico
dc.subjectCães
dc.subjectEmaciação/imunologia
dc.subjectEnsaio de Imunoadsorção Enzimática/veterinária
dc.subjectFeminino
dc.subjectLeishmaniose Visceral/imunologia
dc.subjectMasculino
dc.subjectBaço/imunologia
dc.titleAssociations among immunological, parasitological and clinical parameters in canine visceral leishmaniasis: Emaciation, spleen parasitism, specific antibodies and leishmanin skin test reaction.
dc.typeArticle


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