Eosinophils are part of the granulocyte response in tuberculosis and promote host resistance in mice

dc.creatorBohrer, Andrea C.
dc.creatorCastro, Ehydel
dc.creatorHu, Zhidong
dc.creatorQueiroz, Artur Trancoso Lopo de
dc.creatorTocheny, Claire E.
dc.creatorAssmann, Maike
dc.creatorSakai, Shunsuke
dc.creatorNelson, Christine
dc.creatorBaker, Paul J.
dc.creatorMa, Hui
dc.creatorWang, Lin
dc.creatorZilu, Wen
dc.creatorBruyn, Elsa du
dc.creatorRiou, Catherine
dc.creatorKauffman, Keith D.
dc.creatorTuberculosis Imaging Program
dc.creatorMoore, Ian N.
dc.creatorDel Nonno, Franca
dc.creatorPetrone, Linda
dc.creatorGoletti, Delia
dc.creatorMartineau, Adrian R.
dc.creatorLowe, David M.
dc.creatorCronan, Mark R.
dc.creatorWilkinson, Robert J.
dc.creatorBarry, Clifton E.
dc.creatorVia, Laura E.
dc.creatorBarber, Daniel L.
dc.creatorKlion, Amy D.
dc.creatorAndrade, Bruno de Bezerril
dc.creatorSong, Yanzheng
dc.creatorWong, Ka-Wing
dc.creatorBarber, Katrin D. Mayer
dc.date2021-09-01T14:06:42Z
dc.date2021-09-01T14:06:42Z
dc.date2021
dc.date.accessioned2023-09-26T22:36:14Z
dc.date.available2023-09-26T22:36:14Z
dc.identifierBOHRER, Andrea C. et al. Eosinophils are part of the granulocyte response in tuberculosis and promote host resistance in mice. Journal of Experimental Medicine, v. 218, n. 10, p. 1-20, 04 Aug. 2021.
dc.identifier0022-1007
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/48882
dc.identifier10.1084/jem.20210469
dc.identifier1540-9538
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8880890
dc.descriptionBruno B. Andrade, Artur T.L. Queiroz. Fundação Oswaldo Cruz. Instituto Gonçalo Muniz. Salvador, BA, Brasil.
dc.descriptionAndrea C. Bohrer (National Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Clinical Immunology and Microbiology. Inflammation and Innate Immunity Unit. Bethesda, MD, United States of America.); Ehydel Castro (National Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Clinical Immunology and Microbiology. Inflammation and Innate Immunity Unit. Bethesda, MD, United States of America.); Zhidong Hu (Fudan University. Shanghai Public Health Clinical Center. Department of Scientific Research. Shanghai, China / Fudan University. Shanghai Emerging and Re-emerging Infectious Disease Institute. Tuberculosis Center. Shanghai, China.); Artur T. L. Queiroz (The KAB Group / Multinational Organization Network Sponsoring Translational and Epidemiological Research. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.); Claire E. Tocheny (National Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Clinical Immunology and Microbiology. Inflammation and Innate Immunity Unit. Bethesda, MD, United States of America.); Maike Assmann (National Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Clinical Immunology and Microbiology. Inflammation and Innate Immunity Unit. Bethesda, MD, United States of America.); Shunsuke Sakai (National Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Parasitic Diseases. T Lymphocyte Biology Section. Bethesda, MD, United States of America.); Christine Nelson (National Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Parasitic Diseases. T Lymphocyte Biology Section. Bethesda, MD, United States of America.); Paul J. Baker (National Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Clinical Immunology and Microbiology. Inflammation and Innate Immunity Unit. Bethesda, MD, United States of America.); Hui Ma (Fudan University. Shanghai Public Health Clinical Center. Department of Scientific Research. Shanghai, China / Fudan University. Shanghai Emerging and Re-emerging Infectious Disease Institute. Tuberculosis Center. Shanghai, China.); Lin Wang (Fudan University. Shanghai Emerging and Re-emerging Infectious Disease Institute. Tuberculosis Center. Shanghai, China / Fudan University. Shanghai Public Health Clinical Center. Department of Thoracic Surgery. Shanghai, China.); Wen Zilu (Fudan University. Shanghai Emerging and Re-emerging Infectious Disease Institute. Tuberculosis Center. Shanghai, China / Fudan University. Shanghai Public Health Clinical Center. Department of Thoracic Surgery. Shanghai, China.); Elsa du Bruyn (University of Cape Town. Institute of Infectious Disease and Molecular Medicine. Wellcome Centre for Infectious Diseases Research in Africa. Cape Town, South Africa.); Catherine Riou (University of Cape Town. Institute of Infectious Disease and Molecular Medicine. Wellcome Centre for Infectious Diseases Research in Africa. Cape Town, South Africa.); Keith D. Kauffman (National Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Parasitic Diseases. T Lymphocyte Biology Section. Bethesda, MD, United States of America.); Tuberculosis Imaging Program (National Institutes of Health. National Institute of Allergy and Infectious Diseases. Division of Intramural Research. Tuberculosis Imaging Program. Bethesda, MD, United States of America.); Ian N. Moore (National Institutes of Health. National Institute of Allergy and Infectious Diseases. Comparative Medicine Branch. Infectious Disease Pathogenesis Section. Bethesda, MD, United States of America.); Franca Del Nonno (Istituto Di Ricovero e Cura a Carattere Scientifico. National Institute for Infectious Diseases "L. Spallanzani". Pathology Unit. Rome, Italy.); Linda Petrone (Istituto Di Ricovero e Cura a Carattere Scientifico. Department of Epidemiology and Preclinical Research National Institute for Infectious Diseases. Translational Research Unit. Rome, Italy.); Delia Goletti (Istituto Di Ricovero e Cura a Carattere Scientifico. Department of Epidemiology and Preclinical Research National Institute for Infectious Diseases. Translational Research Unit. Rome, Italy.); Adrian R. Martineau (University College London. Institute of Immunity and Transplantation. London, United Kingdom.); David M. Lowe (University College London. Institute of Immunity and Transplantation. London, United Kingdom.); Mark R. Cronan (Max Planck Institute for Infection Biology. In Vivo Cell Biology of Infection Unit. Berlin, Germany / Duke University School of Medicine. Department of Molecular Genetics and Microbiology. Durham, NC, United States of America.); Robert J. Wilkinson (University of Cape Town. Institute of Infectious Disease and Molecular Medicine. Wellcome Centre for Infectious Diseases Research in Africa. Cape Town, South Africa / Imperial College London. Department of Infectious Diseases. London, United Kingdom.); Clifton E. Barry, III (University of Cape Town. Institute of Infectious Disease and Molecular Medicine. Wellcome Centre for Infectious Diseases Research in Africa. Cape Town, South Africa / National Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Clinical Immunology and Microbiology. Tuberculosis Research Section. Bethesda, MD, United States of America.); Laura E. Via (National Institutes of Health. National Institute of Allergy and Infectious Diseases. Division of Intramural Research. Tuberculosis Imaging Program. Bethesda, MD, United States of America / National Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Clinical Immunology and Microbiology. Tuberculosis Research Section. Bethesda, MD, United States of America.); Daniel L. Barber (National Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Parasitic Diseases. T Lymphocyte Biology Section. Bethesda, MD, United States of America.); Amy D. Klion (National Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Parasitic Diseases. Human Eosinophil Section. Bethesda, MD, United States of America.); Bruno B. Andrade (The KAB Group / Multinational Organization Network Sponsoring Translational and Epidemiological Research. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.); Yanzheng Song (Fudan University. Shanghai Emerging and Re-emerging Infectious Disease Institute. Tuberculosis Center. Shanghai, China / Fudan University. Shanghai Public Health Clinical Center. Department of Thoracic Surgery. Shanghai, China.); Ka-Wing Wong (Fudan University. Shanghai Public Health Clinical Center. Department of Scientific Research. Shanghai, China / Fudan University. Shanghai Emerging and Re-emerging Infectious Disease Institute. Tuberculosis Center. Shanghai, China.); Katrin D. Mayer-Barber (National Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Clinical Immunology and Microbiology. Inflammation and Innate Immunity Unit. Bethesda, MD, United States of America).
dc.descriptionDivision of Intramural Research, National Institute of Allergy and Infectious Diseases and the National Natural Science Foundation of China (grant no. 81770010 to K.-W. Wong)
dc.descriptionNational Institutes of Health (grant no. U01AI115940)
dc.descriptionWellcome Trust (grant nos. 104803 and 203135)
dc.descriptionCancer Research UK, UK Research and Innovation, and Wellcome Trust (FC0010218)
dc.descriptionNational Council for Scientific and Technological Development (senior fellowship)
dc.descriptionIntramural Research Program of the Oswaldo Cruz Foundation, Brazil
dc.descriptionHost resistance to Mycobacterium tuberculosis (Mtb) infection requires the activities of multiple leukocyte subsets, yet the roles of the different innate effector cells during tuberculosis are incompletely understood. Here we uncover an unexpected association between eosinophils and Mtb infection. In humans, eosinophils are decreased in the blood but enriched in resected human tuberculosis lung lesions and autopsy granulomas. An influx of eosinophils is also evident in infected zebrafish, mice, and nonhuman primate granulomas, where they are functionally activated and degranulate. Importantly, using complementary genetic models of eosinophil deficiency, we demonstrate that in mice, eosinophils are required for optimal pulmonary bacterial control and host survival after Mtb infection. Collectively, our findings uncover an unexpected recruitment of eosinophils to the infected lung tissue and a protective role for these cells in the control of Mtb infection in mice.
dc.description2022-02-04
dc.formatapplication/pdf
dc.languageeng
dc.publisherRockefeller University Press
dc.rightsrestricted access
dc.subjectEosinófilos
dc.subjectTuberculose
dc.subjectMycobacterium tuberculosis
dc.subjectGranulócitos
dc.subjectInfecções
dc.subjectEosynophils
dc.subjectTuberculosis
dc.subjectMycobacterium tuberculosis
dc.subjectGranulocytes
dc.subjectInfections
dc.titleEosinophils are part of the granulocyte response in tuberculosis and promote host resistance in mice
dc.typeArticle


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