Dissociation between vasodilation and Leishmania infection-enhancing effects of sand fly saliva and maxadilan

dc.creatorSousa, Fábio Castro
dc.creatorSilva, Moacir Paranhos
dc.creatorSherlock, Ítalo Rodrigues de Araújo
dc.creatorPaixão, Mariza S
dc.creatorPontes-de-Carvalho, Lain Carlos
dc.creatordosSantos, Washington Luis Conrado
dc.date2013-02-01T18:16:14Z
dc.date2013-02-01T18:16:14Z
dc.date2001
dc.date.accessioned2023-09-26T22:36:08Z
dc.date.available2023-09-26T22:36:08Z
dc.identifierSOUSA, F. C. et al. Dissociation between vasodilation and Leishmania infection-enhancing effects of sand fly saliva and maxadilan. Memórias do Instituto Oswaldo Cruz, v. 96, n. 7, p.997-999, 2001.
dc.identifier0074-0276
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/6289
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8880877
dc.descriptionIn this study, the ability of maxadilan and Lutzomyia longipalpis salivary gland lysate to enhance the infection of CBA mice by Leishmania major and of BALB/c mice by L. braziliensis was tested. No difference was observed between sizes of lesion in CBA mice infected with L. major and treated or not with salivary gland lysate or maxadilan, although they were injected in concentrations that induced cutaneous vasodilation. Although parasites were more frequently observed in foot pads and spleens of animals treated with maxadilan than in the animals treated with salivary gland lysate or saline, the differences were small and not statistically significant. The lesions in BALB/c mice infected with L. braziliensis and treated with maxadilan were slightly larger than in animals that received Leishmania alone. Such differences disappeared 14 weeks after infection, and were statistically significant only in one of two experiments.
dc.formatapplication/pdf
dc.languageeng
dc.rightsopen access
dc.subjectLutzomyia longipalpis saliva
dc.subjectMaxadilan
dc.subjectLeishmania major
dc.subjectLeishmania braziliensis
dc.subjectVasodilation
dc.subjectLeishmaniose Cutânea/parasitologia
dc.subjectPsychodidae/química
dc.subjectVasodilatadores/farmacologia
dc.subjectExtratos de Tecidos/farmacologia
dc.subjectLeishmania/patogenicidade
dc.subjectLeishmaniose Cutânea/imunologia
dc.subjectLeishmaniose Cutânea/patologia
dc.subjectPsychodidae/efeitos de drogas
dc.subjectCamundongos Endogâmicos BALB C
dc.subjectLeishmania braziliensis/patogenicidade
dc.subjectLeishmania major
dc.subjectGlândulas Salivares/química
dc.subjectGlândulas Salivares/efeitos de drogas
dc.subjectAnimais
dc.subjectCamundongos
dc.titleDissociation between vasodilation and Leishmania infection-enhancing effects of sand fly saliva and maxadilan
dc.typeArticle


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