Quadrivalent HPV vaccine efficacy against disease related to vaccine and non-vaccine HPV types in males.

dc.creatorGoldstone, Stephen
dc.creatorJessen, Heiko
dc.creatorPalefsky, Joel M
dc.creatorGiuliano, Anna R
dc.creatorMoreira Júnior, Edson Duarte
dc.creatorVardas, Eftyhia
dc.creatorAranda, Carlos
dc.creatorHillman, Richard J
dc.creatorFerris, Daron G
dc.creatorCoutlee, Francois
dc.creatorMarshall, J. Brooke
dc.creatorVuocolo, Scott
dc.creatorHaupt, Richard M
dc.creatorGuris, Dalya
dc.creatorGarner, Elizabeth I. O
dc.date2014-11-04T18:49:21Z
dc.date2014-11-04T18:49:21Z
dc.date2013
dc.date.accessioned2023-09-26T22:35:29Z
dc.date.available2023-09-26T22:35:29Z
dc.identifierGOLDSTONE, S. E. et al. Quadrivalent HPV vaccine efficacy against disease related to vaccine and non-vaccine HPV types in males. Vaccine, v. 31, n. 37, p. 3849-3855, 2013.
dc.identifier1873-2518
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/8716
dc.identifierdx.doi.org/10.1016/j.vaccine.2013.06.057
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8880756
dc.descriptionA small number of HPV types are related to a majority of HPV-related neoplastic lesions in humans. High-risk types such as HPV 16 and 18 are most often implicated, although other oncogenic and non-oncogenic HPV types can cause disease in men. The efficacy of the quadrivalent HPV vaccine (qHPV) against external genital lesions and intra-anal disease related to HPV in men has been demonstrated. This report examines the vaccine's efficacy against disease due to 10 additional non-vaccine HPV types, as well as efficacy regardless of HPV detection. The data presented suggest that vaccinating males against HPV 6, 11, 16 and 18 protects them against most vaccine HPV-type related anogenital disease. However, significant efficacy against disease due to non-vaccine HPV types was not seen. In addition, the data do not provide any evidence that vaccination with qHPV vaccine will increase the likelihood of disease caused by non-vaccine types in the short term
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier Ltd
dc.rightsopen access
dc.subjectHPV
dc.subjectYoung
dc.subjectMales
dc.subjectMen who have sex with mena
dc.subjectNeoplasias do Ânus/virologia
dc.subjectInfecções por Papillomavirus/prevenção & controle
dc.subjectInfecções por Papillomavirus/virologia
dc.subjectVacinas contra Papillomavirus/uso terapêutico
dc.subjectAdolescente
dc.subjectAdulto
dc.subjectCanal Anal/patologia
dc.subjectNeoplasias do Ânus/epidemiologia
dc.subjectNeoplasias dos Genitais Masculinos/patologia
dc.subjectPapillomavirus Humano 11/patogenicidade
dc.subjectPapillomavirus Humano 16/patogenicidade
dc.subjectHumanos
dc.subjectMasculino
dc.subjectInfecções por Papillomavirus/epidemiologia
dc.subjectResultado do Tratamento
dc.subjectAdulto Jovem
dc.titleQuadrivalent HPV vaccine efficacy against disease related to vaccine and non-vaccine HPV types in males.
dc.typeArticle


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