CCR5 Antagonist Maraviroc Inhibits Acute Exacerbation of Lung Inflammation Triggered by Influenza Virus in Cigarette Smoke-Exposed Mice

dc.creatorFerrero, Maximiliano Ruben
dc.creatorGarcia, Cristiana Couto
dc.creatorAlmeida, Marcella Dutra de
dc.creatorSilva, Jullian Torres Braz da
dc.creatorInsuela, Daniella Bianchi Reis
dc.creatorFerreira, Tatiana Paula Teixeira
dc.creatorCoutinho, Diego de Sá
dc.creatorAzevedo, Carolina Trindade de
dc.creatorSilva, Patrícia Machado Rodrigues e
dc.creatorMartins, Marco Aurélio
dc.date2021-09-17T17:55:11Z
dc.date2021-09-17T17:55:11Z
dc.date2021
dc.date.accessioned2023-09-26T22:35:25Z
dc.date.available2023-09-26T22:35:25Z
dc.identifierFERRERO, Maximiliano Ruben et al. CCR5 Antagonist Maraviroc Inhibits Acute Exacerbation of Lung Inflammation Triggered by Influenza Virus in Cigarette Smoke-Exposed Mice. Pharmaceuticals, v. 14, n. 620, 14 p, June 2021.
dc.identifier1999-4923
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/49109
dc.identifier10.3390/ph14070620
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8880740
dc.descriptionInfluenza A virus (IAV) infection is a common cause of acute exacerbations of chronic obstructive pulmonary disease (AECOPD). Since macrophage inflammatory protein 1 α, a chemokine that acts through CC-chemokine receptor (CCR)-5, appears elevated in COPD patients’ airways, we evaluated whether CCR5 antagonist Maraviroc could inhibit the exacerbated lung inflamma tory response noted after IAV H1N1 infection in mice exposed to cigarette smoke (Cs). C57BL/6 mice, subjected or not to Cs inhalation for 11 days, were infected with H1N1 at day 7. Maraviroc (10 mg/kg) or dexamethasone (1 mg/kg) were given in a therapeutic schedule, followed by the analyses of lung function, survival rate, and inflammatory changes. As compared to mice subjected to Cs or H1N1 alone, the insult combination significantly worsened airway obstruction, neutrophil infiltration in the airways, and the survival rate. All changes were sensitive to Maraviroc but not dexamethasone. Maraviroc also reduced the accumulation of neutrophils and macrophages as well as CXCL1 production in the lung tissue, and serum levels of IL-6, whereas comparable viral titers in the lungs were noted in all infected groups. Collectively, these findings suggest that Maraviroc oral treatment could be an effective therapy for controlling acute exacerbations of respiratory diseases such as COPD.
dc.formatapplication/pdf
dc.languageeng
dc.publisherMDPI
dc.rightsopen access
dc.subjectReceptor de quimioterapia
dc.subjectDoença pulmonar obstrutiva crônica
dc.subjectInfluenza A (H1N1)
dc.subjectMaraviroc
dc.subjectChemokine receptor
dc.subjectChronic obstructive pulmonary disease
dc.subjectInfluenza A (H1N1)
dc.subjectMaraviroc
dc.titleCCR5 Antagonist Maraviroc Inhibits Acute Exacerbation of Lung Inflammation Triggered by Influenza Virus in Cigarette Smoke-Exposed Mice
dc.typeArticle


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