Brasil | Article

Leptospira: the dawn of the molecular genetics era for an emerging zoonotic pathogen.

dc.creatorKo, Albert Icksang
dc.creatorGoarant, Cyrille
dc.creatorPicardeau, Mathieu
dc.date2015-11-13T12:47:49Z
dc.date2015-11-13T12:47:49Z
dc.date2009
dc.date.accessioned2023-09-26T22:34:53Z
dc.date.available2023-09-26T22:34:53Z
dc.identifierHO, A. I.; GOARANT, C.; PICARDEAU, M. Leptospira: the dawn of the molecular genetics era for an emerging zoonotic pathogen. Nature Review Microbiology, v. 7, n. 10, p. 736-747, 2009.
dc.identifier1740-1534
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/12224
dc.identifier10.1038/nrmicro2208.
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8880630
dc.descriptionLeptospirosis is a zoonotic disease that has emerged as an important cause of morbidity and mortality among impoverished populations. One hundred years after the discovery of the causative spirochaetal agent, little is understood about Leptospira spp. pathogenesis, which in turn has hampered the development of new intervention strategies to address this neglected disease. However, the recent availability of complete genome sequences for Leptospira spp. and the discovery of genetic tools for their transformation have led to important insights into the biology of these pathogens and their pathogenesis. We discuss the life cycle of the bacterium, the recent advances in our understanding and the implications for the future prevention of leptospirosis.
dc.formatapplication/pdf
dc.languageeng
dc.publisherNature Publishing Group
dc.rightsopen access
dc.subjectLeptospira/genética
dc.subjectLeptospira/patogenicidade
dc.subjectLeptospirose/microbiologia
dc.subjectAnimais
dc.subjectVacinas Bacterianas/imunologia
dc.subjectModelos Animais de Doenças
dc.subjectGenoma Bacteriano
dc.subjectHumanos
dc.subjectLeptospira/crescimento & desenvolvimento
dc.subjectLeptospira/imunologia
dc.subjectLeptospirose/epidemiologia
dc.subjectLeptospirose/prevenção & controle
dc.subjectLeptospirose/transmissão
dc.subjectVirulência
dc.titleLeptospira: the dawn of the molecular genetics era for an emerging zoonotic pathogen.
dc.typeArticle


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